冠状动脉内支架置入后的炎症反应

Inflammatory reactions following coronary stenting

冠状动脉支架置入对血管内膜造成的机械性损伤以及支架作为一种异体物质对血管壁的刺激,导致血小板和炎症细胞聚集、浸润,释放炎症介质、趋化因子、黏附分子和生长因子,促进血管平滑肌细胞的迁移和增殖。支架置入后炎症反应与血管内再狭窄的发生关系密切。应用具有抗血管平滑肌细胞增生、抗炎症反应的药物制备药物支架,可以减少机体炎症反应的强度和持续时间,提高支架置入操作技术水平可减少支架置入过程中对血管壁的损伤,降低血管内再狭窄的发生率。

Coronary stent can cause mechanical injury to tunica intima and stimulation to vessel wall, resulting to platelet and inflammatory cell aggregation and infiltration, release of inflammation mediators, chemotatic factor, adhesion molecule and growth factor, and promoting migration and proliferation of vascular smooth muscle cells. The inflammatory reaction post stenting is highly correlated with intravascular restenosis. The drug-eluting stent against proliferation of vascular smooth muscle cells and inflammatory reaction can reduce the intensity and duration of body inflammatory reaction, improve stent technique, relieve damage of stenting to vessel wall, and reduce incidence of intravascular restenosis.