NDRG1及nm23蛋白在大肠腺癌中的表达及其相互关系

Correlation and Expression of NDRG1 and nm23 in Colorectal Adenocarcinomas

目的研究NDRG1、nm23蛋白在大肠腺癌淋巴结转移中的作用,并探讨二者在大肠腺癌淋巴结转移中的相互关系.方法采用免疫组化方法,观察无淋巴结转移的大肠腺癌、有淋巴结转移的大肠腺癌中NDRG1蛋白及nm23蛋白表达特点.结果NDRG1蛋白表达与大肠腺癌有无淋巴结转移差异有统计学意义(P<0.05),且呈正相关关系(P<0.05).nm23蛋白表达与大肠腺癌有无淋巴结转移差异有统计学意义(P<0.05),但呈负相关关系(P<0.05).无淋巴结转移的大肠腺癌及有淋巴结转移的大肠腺癌中NDRG1蛋白与nm23蛋白表达之间均未见相关性(P>0.05).结论NDRG1蛋白与nm23蛋白可能在大肠腺癌淋巴结转移的不同环节发挥作用.

Objective To study the correlations and functions of NDRG1 and nm23 protein in the metastases of colorectal adenocarcinoma. Methods NDRG1 and nm23 were detected at their protein levels by immunohistochemical （IHC） staining technique in colorectal carcinomas with no regional lymph nodes metastasis and colorectal carcinomas with regional lymph nodes metastasis. Results There was significant difference between the expressions of NDRG1 in colorectal carcinomas with no regional lymph nodes metastasis and those with regional lymph nodes metastasis, and the correlation was positive （P 〈 0.05）. Most carcinomas with regional lymph nodes metastasis showed reduced nm23 expression, as compared to the carcinomas with no regional lymph nodes metastasis, and the correlation was negative （P 〈 0.05）. There was no obvious correlation between the expressions of NDRG1 and the expressions of nm23. Conclusion NDRG1 protein and nm23 protein may play different roles respectively in the different processes of colorectal carcinomas metastasis.