骨桥蛋白在颅咽管瘤中的表达及其与预后的关系

Expression of Osteopontin in Craniopharyngioma and Its Correlation with Prognosis

目的检测颅咽管瘤组织中骨桥蛋白(OPN)的表达,并观察其与肿瘤复发的关系.方法对32例釉质上皮型和33例鳞状乳头型颅咽管瘤病例,根据各组术后复发情况再分为复发组和非复发组,采用免疫组化(SP法)测定骨桥蛋白在各组中的表达情况.结果32例釉质上皮型组11例患者复发,33例鳞状乳头型组3例患者复发.釉质上皮型组与鳞状乳头型组间复发率和骨桥蛋白表达差异均有统计学意义(P<0.05);各组中复发组与非复发组间骨桥蛋白表达差异有统计学意义(P<0.05).结论颅咽管瘤的病理亚型和骨桥蛋白的表达与肿瘤预后及复发有关,可能预测肿瘤复发危险性.

Objective To investigate the expression of osteopontin in tissue sections of craniopharyngioma and observe the relation between the expression and the recrudescence of patients with craniopharyngiomas, Methods The study were composed of 32 adamantine epithelioma （AE） patients and 33 squamous papillary tumor （SP） patients, each group was divided into recurrence group and recurrence-free group. The expression of osteopontin was evaluated in each group by immunohistochemical method （avidin-biotin-peroxidase）. Results 11 of 32 AE patients and 3 of 33 SP patients had recurred during follow-up. Osteopontin expression and recurrence rate showed significant difference between AE group and SP group （P 〈 0.05 ）. Osteopontin expression between recurrence group and recurrence-free group was subtype and osteopontin expression of craniopharyngiomas useful in predicting the risk of tumor relapse. significantly different （P 〈 0.05）. Conclusions The are related to the prognosis of tumor and thus may be useful in predicting the risk of tumor relapse.