妊娠期糖耐量、瘦素和脂联素水平变化的临床分析

Clinical Analysis of Leptin and Adpionectin Levels with Gestational Diabetes Mellitus and Gestational Impaired Glucose Tolerance

目的探讨血清瘦素和脂联素水平变化与妊娠期糖耐量异常程度的关系及其影响.方法根据血糖检测和葡萄糖耐量试验的结果把68例研究对象分为妊娠期糖尿病组、妊娠期糖耐量低减组和糖耐量正常组.同时检测3组孕妇的血清瘦素和脂联素浓度.结果妊娠期糖尿病组和妊娠期糖耐量低减组的瘦素水平均高于糖耐量正常组(P<0.05),脂联素水平均低于糖耐量正常组(P<0.05),但前两组之间相比无明显差异(P<0.05).瘦素水平与妊娠期糖尿病和妊娠期糖耐量低减的发病率呈正性相关,而脂联素则呈负性相关.结论瘦素和脂联素均可作为早期预测妊娠期糖尿病或妊娠期糖耐量低减的指标.

Objective To discuss the relationships and effects on leptin and adpionectin with gestational diabetes mellitus and gestational impaired glucose tolerance. Methods 68 pregnant women were divided into 3 groups （gestational diabetes mellitus group, gestational impaired glucose tolerance group and normal glucose tolerance group） according to the screening result of blood glucose test and 75 g oral glucose overload test. Meanwhile, concentration of leptin and adpionectin was determined. Results Leptin levels of gestational diabetes mellitus group and gestational impaired glucose tolerance group were higher than normal tolerance group （P 〈 0.05）, but adpionectin levels of the prior two groups were lower than normal diabetes group （P 〈 0.05）. There was no significant difference between the prior two groups （P 〉 0.05 ）. Leptin levels had positive correlation with the morbidities of gestational diabetes mellitus and gestational impaired glucose tolerance while adpionectin levels were negative. Conclusion Leptin and adpionectin levels have predictive value for gestational diabetes mellitus and gestational impaired glucose tolerance.