绞股蓝总皂苷对家兔离体十二指肠平滑肌收缩活动的影响

Effects of Gypenosides on contraction of isolated duodenum smooth muscle of rabbits

目的:观察绞股蓝总皂苷对家兔离体十二指肠平滑肌收缩活动的影响。方法:采用常规十二指肠平滑肌标本离体灌流的实验方法,加入不同浓度的绞股蓝总皂苷(0.01%～1.00%),通过Medlab生物信号采集处理系统分别记录加药前后十二指肠平滑肌的收缩曲线。结果:不同浓度的绞股蓝总皂苷均可以显著降低十二指肠平滑肌的收缩幅度,与绞股蓝总皂苷的浓度呈剂量依赖性关系。结论:绞股蓝总皂苷可以抑制家兔离体十二指肠平滑肌的自律性收缩活动。

AIM： To investigate the efftct of Gypenosides on contraction of isolated duodenum smooth mustle of rabbits. METHODS： The routine experimental method of isolated duodenal smooth muscle of rabbits were used. The contraction curves of isolated duodenum smooth mustle before and after administration of different concentrations of Gypenosides （0.01% - 1.00%） were recorded by Medlab biological information collecting system. RESULTS： Different concentrations of Gypenosides significantly reduced the contraction amplitude of isolated duodenum smooth mustle of rabbits, and showed a dose-dependent relationship. CONCLUSION： Gypenosides can inhibit the contraction of isolated duodenum smooth muscle of rabbits.