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抗环瓜氨酸肽抗体在类风湿关节炎发病机制病情进展及治疗监测中的意义 被引量：3

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摘要 20世纪末，随着对类风湿关节炎（rheumatoid arthritis，RA）研究的深入，逐步发现抗核周因子（APF）、抗角蛋白抗体（AKA）以及抗聚角蛋白微丝蛋白抗体（AFA）对RA的诊断具有高度特异性，且这些抗体在化学结构上具相关性，抗原决定簇中都含有瓜氨酸。瓜氨酸是一种稀有氨基酸，来源于翻译后酶修饰的精氨酸残基。2000年，荷兰Schellekens等将上述由19个氨基酸残基组成的一条瓜氨酸肽链中的两个丝氨酸替换成半胱氨酸，
作者 林宁 梁淑慧
机构地区 广东省第二人民医院中医科 广州中医药大学第一附属医院检验科
出处 《中华风湿病学杂志》 CAS CSCD 2008年第6期418-421,共4页 Chinese Journal of Rheumatology
基金 广东省中医药局建设中医药强省科研课题（2006-31）
关键词 抗环瓜氨酸肽抗体 类风湿关节炎 治疗监测 病情进展 发病机制 抗聚角蛋白微丝蛋白抗体 氨基酸残基 抗角蛋白抗体
分类号 R593.22 [医药卫生—内科学] R394 [医药卫生—医学遗传学]
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参考文献28

  • 1Schellekens GA, Dejong BAW, Vanden Hoogen FHJ, et al. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis specific auto-antibodies. J Clin Invest, 1998, 101: 2735.
  • 2Schellekens GA, Visser H, dejong BAW, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum, 2000. 43: 15512.
  • 3Raptopoulou A, Sidiropoulos P, Katsouraki M, et al. Anti-citrulline antibodies in the diagnosis and prognosis of rheumatoid arthritis: evolving concepts. Crit Rev Clin Lab Sci, 2007, 44: 339-363.
  • 4Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Int Med, 2007, 146: 797-808.
  • 5Matsui T, Shimada K, Ozawa N, et al. Diagnostic utility of anticyclic citrullinated peptide antibodies for very early rheumatoid arthritis. J Rheumatol, 2006, 33: 2390-2397.
  • 6Stolt P, Bengtsson C, Nordmark B, et al. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis, 2003, 62: 835-841.
  • 7Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum, 2006, 54: 38-46.
  • 8Linn-Rasker SP, Van der Helm-van Mil AH, Van Gaalen FA, et al. Smoking is a risk factor for anti-CCP antibodies only in RA patients that carry HLA-DRBI shared epitope alleles. Ann Rheum Dis, 2006, 65: 366-371.
  • 9Pedersen M, Jacobsen S, Garred P, et al. Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark. Arthritis Rheum, 2007, 56: 1446-1453.
  • 10Pedersen M, Jacobsen S, Klarlund M, et al. Environmental risk factors differ between rheumatoid arthritis with and without autoantibodies against cyclic eitrullinated peptides. Arthritis Res Ther, 2006, 8: 133.

二级参考文献7

  • 1Visser H. How to diagnose rheumatoid arthritis early: a prediction model for persistent erosive arthritis. Arthritis Rheum, 2002, 46:357-365.
  • 2Schellekens GA, Visser H, de Jong BAW, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic cirtrullinated peptide. Arthritis Rheum, 2000, 43: 155-163.
  • 3Sharp JT, Young DY, Bluhm GB, et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis. Arthritis Rheum,1985, 28: 1326-1335.
  • 4Kroot EJJA, de Jong BAW, van Leeuwen MA, et al. The prognostic value of anti- cyclic cirtrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum, 2000,43: 1831-1835.
  • 5Bas S, Perneger TY. Diagnostic tests for rheumatoid arthritis:comparison of anti-cyclic cirtrullinated peptide antibodies, antikeratin antibodies and IgM rheumatoid factors. Rheumatology,2002, 41: 809-814.
  • 6曾小峰,艾脉兴,甘晓丹,史艳萍,宋琴芳,唐福林.抗环瓜氨酸肽抗体检测在类风湿关节炎中的意义[J].中华风湿病学杂志,2001,5(5):281-284. 被引量：290
  • 7崔天盆,谢俊丽,余立凯,胡丽华,沈凌讯,吴健民.抗CCP、抗RA33等4种自身抗体在类风湿关节炎诊断中的应用[J].上海医学检验杂志,2003,18(4):221-222. 被引量：15

共引文献50

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二级引证文献4

中华风湿病学杂志
2008年 第6期

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