125例非霍奇金淋巴瘤患者的临床和预后分析(英文)

Clinical and Prognostic Analysis of 125 Cases of Non-Hodgkin's Lymphoma

本研究旨在分析非霍奇金淋巴瘤(NHL)的临床资料,探讨影响预后的因素。对125例NHL病例进行了回溯性分析。结果发现,125例病例中B-NHL85例(68%),T-NHL35例(28%),不能分类的5例(4%)。B-NHL易于侵犯骨髓,而T-NHL多伴有B症状,乳酸脱氢酶(LDH)升高,临床分期晚,国际预后指数(IPI)评分高,且T-NHL的3年存活率明显低于B-NHL。生存分析显示,年龄、B症状、LDH水平、临床分期为预后相关因素,免疫分型对预后无显著性影响。骨髓侵犯的发生率为31.2%(39/125),在B-NHL多见。骨髓侵犯方式与年龄、B症状、LDH水平、T/B免疫分型无关,但弥漫型骨髓侵犯多伴有肝脾肿大,且总体生存率明显低于局灶型。结论:年龄、B症状、LDH水平和临床分期是影响NHL预后的主要因素,免疫分型尚不足以成为判断预后的独立因素,骨髓侵犯方式对预后有一定的提示意义。

This study was to investigate the predictive factors influencing prognosis of non-Hodgkin＇s lymphoma （NHL）. The clinical data on 125 cases of NHL were analyzed retrospectively. The results indicated that in 125 cases, the incidence of B cell NHL （B-NHL） was 68% , T cell NHL （T-NHL） was 28%, and uncertained cases wese 4%. B-NHL was with more bone marrow involvement, while T-NHL was associated with more presence of B symptom, in- creased lactate dehydrogenase （ LDH）, advanced clinical stage and higher International Prognostic Index （IPI） scores. For T-NHL and B-NHL, the 3-year overall survival （OS） rate was 41.07% and 71.64% respectively. Age, B symp- tom, LDH level, and clinical stage were associated with OS. Immunophenotyping was not identified as a significant prognostic factor. The incidence of born marrow involvement was 31.2%, mainly in B-NHL. The involvement manner had no relationships with age, B symptom, LDH level and T/B immunophenotyping. Diffuse bone marrow involvement was often linked with hepatosplenomegaly, and its OS was shorter than that focal manner. In conclusion, age, B symptom, LDH level and clinical stage affect NHL survival, while immunophenotyping was not an independent prognostic factor for NHL. The manner of bone marrow involvement helped to predict prognosis.