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中国人群LW血型基因多态性的研究 被引量：5

Polymorphism of LW Blood Group Gene in Chinese Population
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摘要 本研究探讨中国人群Landsteiner-Wiener(LW)血型基因的多态性。随机采集深圳市血液中心160名非血缘关系无偿志愿捐血者外周血样EDTA抗凝血标本,并提取DNA。对这160例DNA标本直接进行LW血型基因的第一外显子测序分析,同时用优化的LWa/LWb等位基因PCR-SSP方法进行了的基因分型。结果表明:在对这160例捐血者基因组DNA的分子生物学研究中发现LW血型等位基因均为LWa纯合子。结论:在中国人群中LWa等位基因更常见,本次研究中100%的献血者LW血型等位基因均为LWa,目前还未发现LWb等位基因。 In order to study the polymorphism of Landsteiner-Wiener （LW） blood group gene in Chinese population, peripheral blood samples anticoagulated with EDTA from 160 unrelated volunteer blood donors were randomly collected, and genomic DNA were extracted. 160 DNA samples were analyzed for exon 1 of LW gene by direct DNA sequencing, and detected for LWa/LWb allele by improved PCR-SSP genotyping. The results showed that all LW allele in 160 donors were LWa homozygous, and the LWa allele occured commonly. In conclusion, LWa allele occurs with inci- dence of 100% of donors in this study, while LWb allele has not been found in Chinese population.
作者 苏宇清 喻琼 刘旭 梁延连 魏天莉
机构地区 深圳市血液中心 大连医科大学
出处 《中国实验血液学杂志》 CAS CSCD 2008年第3期691-693,共3页 Journal of Experimental Hematology
关键词 血型 Landsteiner—Wiener血型 基因多态性 中国人群 blood group Landsteiner-Wiener blood group gene polymorphism Chinese population
分类号 R457.11 [医药卫生—治疗学]
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参考文献11

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二级参考文献12

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共引文献7

同被引文献54

  • 1张玉娴,朱自严.血型抗原与粘附分子[J].中国输血杂志,2006,19(1):83-86. 被引量：8
  • 2杨宝成,苏宇清,魏天莉,喻琼,梁延连,邓志辉.Landsteiner-Wiener血型系统测序分型技术的建立[J].江西医学检验,2007,25(3):223-224. 被引量：5
  • 3Davies J, Day S, Milne A, et al. Haemolytie disease of the foetus and newborn caused by auto anti-LW. Trans-fus Med, 2009, 19 ( 4 ) : 218-219.
  • 4Grandstaff Moulds MK. The LW blood group system: a review. Immunohematology, 2011,27 (4) : 136-142.
  • 5Bailly P, Hermand P, Callebaut I. et al. The LW blood group gly- coprotein is homologous to intercellular adhe-sion molecules. Proc Natl Acad Sci USA, 1994,91 (12) :5306-5310.
  • 6Srivastava K, Almarry NS, Flegel WA. Genetic variation of the whole ICAM4 gene in Caucasians and Affic-an Americans. Transfusion, 2014,54(9) :2315-2324.
  • 7Delahunty M, Zennadi R, Telen MJ. LW protein: a promiscuous integrin receptor activated by adrenergic Tra-nsfus Clin Boil, 2006;13 (1-2) :44-49.
  • 8Parsons SF, Spring FA, Chasis JA, et al. Erythroid cell adhesion molecules Lutheran and LW in health and disease. Baillieres Best Prac Clin Haematol ,1999,12(4) :729-745.
  • 9Sistonen P, Virtaranta-Knowles, Denisova R, et al. The LWb blood group as a marker of prehistoric Baltic migl"atians and admixture. HumHered, 1999,49 (3) : 154-158.
  • 10Delahunty M, Zennadi R, Telen MJ. LW protein: a promiscuous integrin receptor activated by adrenergic signaling. Transfus Clin Biol, 2006, 13(4) :4-9.

引证文献5

二级引证文献11

中国实验血液学杂志
2008年 第3期

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