血小板添加剂研究进展

Advances of Studies on Platelet Additive Solutions——Review

使用血小板添加剂(PAS)部分或者全部替代血浆常温保存血小板具有许多优点,例如可以避免输注大量血浆引起的发热、过敏反应以及循环超负荷;另外可以改善保存环境使血小板活性与止血功能维持在较高水平,节省大量血浆用于其他目的,便于血小板制品病原体灭活等。近20余年来,对于血小板添加剂的研究一直是一个热点,不同配方的血小板添加剂不断有报道,对血小板的保护效果也越来越好。本文就对血小板添加剂的组成成分、各成分的作用、体内外保存效果等研究进展进行了综述。

Platelet additive solutions（PAS） can partly or fully substitute blood plasma during platelet storage in normal air temperature. There are some advantages such as avoiding transfusion of large volume of plasma with possible adverse reactions and circulatory overload, saving plasma for other purposes, improving storage conditions, maintaining the viability and haemostatic function of platelet at normal level, and making it easy to inactivate pathogens. There has been an increasing interest in the study of PAS in the past 20 years, the compositions of different PAS have been reported one after another, and the protective effects of PAS on platelets have become better and better. This article focuses on the advances of studies of the composition of PAS, the functions of the different compositions and platelet quality in vitro and in vivo after storage.