Ku抗体检测的临床意义:32例分析

Clinical significance of anti-Ku antibody detection:Analysis of 32 cases

目的:探讨Ku抗体检测的临床意义.方法:对32例采用间接免疫荧光法检测的Ku抗体阳性患者进行临床回顾性分析.结果:32例患者中,系统性硬化症合并多发性肌炎1例(3.1%),系统性红斑狼疮(SLE)13例(40.6%),类风湿性关节炎(RA)3例(9.4%),干燥综合症4例(12.5%),硬皮病3例(9.4%),其他的自身免疫性疾病4例(12.5%).Ku抗体阳性可在多种疾病中出现,主要是各种类型的自身免疫性疾病.在非自身免疫性疾病中,肿瘤占3.1%,心血管疾病占9.4%.重叠综合症患者的Ku抗体滴度较高(1∶10000),非自身免疫性疾病的Ku抗体滴度较低(1∶320),滴度与病情有一定的相关性.结论:Ku抗体是系统性硬化症合并多发性肌炎相对特有的指标,但Ku抗体阳性时,必须结合患者临床症状进行诊断.Ku抗体是广义上的重叠综合症患者的关鍵的血清学标志物.血小板减小性紫癜合并其他自身免疫性疾病,自身免疫性疾病合并结核感染等疾病中Ku抗体具有一个重要的提示作用.

AEVI： To investigate the clinical significance of anti- Ku antibody detection. METHODS： Thirty-two cases with anti- Ku antibody positivity proved by indirect immunofluorescence assay were retrospectively analyzed with regard to their clinical data. RESULTS： Of the 30 cases, the positivity rate of anti-Ku antibodies was 3. 1% in systemic sclerosis-polymyositis （SSc-PM） overlap syndrome, 40. 6% in systemic lupus erythmatosus （SLE）, 9. 4% in rheumatoid arthritis （RA）, 12. 5% in Sjogren＇s syndrome, 9.4% in localized scleroderma, 12. 5% in other autoimmune diseases. Anti-Ku antibody was positive in many kinds of diseases, mainly in various kinds of auto-immune diseases. For non-autoimmune diseases, the positivity rate of anti- Ku antibodies was 3.1% in cancer, and 9.4% in cardiovascular disease. The patients with overlap syndrome had the higher titer （ 1：10 000）, and the titer was lower （1：320） in non-autoimmune diseases; it was associated with illness. CONCLUSION： The anti-Ku antibody is relatively specific for SSc-PM overlap connective tissue disease. If anti-Ku antibody is positive, it＇s necessary to make the diagnosis by considering the clinical characteristics of patients. Anti-Ku antibody is a pivotal serological marker for broadly overlap syndrome. It plays an important role in broadly overlap syndrome, such as immune thrombocytopenic purpura overlapped with other autoimmune diseases, autoimmune diseases overlapped with tuberculosis infection, etc.