摘要
目的:探讨金属硫蛋白(MT)在子宫内膜癌中的表达及与雌孕激素受体(ER、PR)表达的关系。方法:应用免疫组织化学方法检测45例子宫内膜癌中MT及ER、PR的表达。结果:在子宫内膜癌中,MT的表达与手术-病理分期和组织学分级密切相关(P<0·05),但与肌层浸润无明显关系。另外,MT的表达还与ER、PR的表达呈负相关(P<0·05)。结论:联合测定ER、PR和MT含量有助于子宫内膜癌的诊断、治疗及预测预后。
Objective： To explore the expression of metallothionein （MT） in endometrial carcinoma and its relationship with expression of estrogen receptor （ER） and progesterone receptor （PR） . Methods： The expression of MT, ER and PR were examined in 45 cases of endometrial carcinoma by immunohistochemistry staining. Resttlts： The expression of MT in endometrial carcinoma was correlated with histological grade and surgical -pathological stage （P 〈0. 05）, but not with the invasion to myometrium. Moreover, MT expression was inversely correlated with ER and PR expression （ P 〈 0. 05 ） . Conclusion： The essays of ER, PR and MT may be valuable to the diagnosis, treatment and prognostic evaluation of endometrial carcinoma.
出处
《中国妇幼保健》
CAS
北大核心
2008年第17期2428-2430,共3页
Maternal and Child Health Care of China
关键词
子宫内膜癌
金属硫蛋白
雌激素受体
孕激素受体
免疫组织化学
Endometrial carcinoma
Metallothionein
Estrogen receptor
Progesterone receptor
Immunohistochemistry
