期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

影响蛋白质翻译终止因素的探讨

Discussion on factors of influencing translation termination
下载PDF
导出
摘要 翻译终止是蛋白质合成的最后一步,它包括肽酰t-RNA的水解以及新生肽链的释放。然而翻译终止并不是一个简单的终止过程,不仅有多种因素(如释放因子、终止密码子的上下游序列、反式作用因子)影响翻译终止的效率,而且其本身也可以作为调节基因表达的一个控制点。影响翻译终止效率因素的研究,对于蛋白质翻译调控及某些遗传病、癌症的治疗具有重要意义。 Translation termination is the last step of protein biosynthesis, which contains hydrolysis of peptidyl-tRNA and release of renascent peptide. It is not a simple process, not only some factors affect efficiency of translation termination, such as release factor, context of stop codon and trans-acting factors, but also translation termination itself plays as a control point of regulation of gene expression. Researches on factors of influencing translation termination have great importance for regulating protein translation, curing genetic dieases and cancers.
作者 耿丽丽 张杰 朱延明 柏锡
机构地区 东北农业大学生命科学学院 中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室
出处 《东北农业大学学报》 CAS CSCD 2008年第5期141-144,共4页 Journal of Northeast Agricultural University
基金 国家自然科学基金(30370909) 国家转基因专项
关键词 翻译终止 释放因子 终止密码子的上下游序列 反式作用因子 translation termination release factor context of stop codon trans-acting factors
分类号 Q7 [生物学—分子生物学]
  • 相关文献

参考文献16

  • 1Song H, Mugnier P, Das A, et al. The crystal structure of human eukaryotic release factor eRF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis[J]. Cell, 2000, 100(3): 311-321.
  • 2Bertram G, Bell H A, Ritchie D W, et al. Terminating eukaryote translation: domainl of release factor eRF1 functions in stop codon recognition[J]. RNA, 2000(6): 1236-1247.
  • 3Frolova L Y, Tsivkovskii R Y, Sivolobova G F et al. Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hyd-rolysis[J]. RNA, 1995(5): 1014-1020.
  • 4Ito K, Ebihara K, Nakamura Y. The stretch of C-terminal acidic amino acids.of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast[J]. RNA, 1998(4): 958-972.
  • 5Liang H, Wong J Y, Bao Q, et al. Decoding the decoding region: analysis of eukaryotic release factor(eRF1) stop codon-binding residues [J]. J Mol Evol, 2005, 60(3): 337-344.
  • 6Kolosov P, Frolova L, Seit-Nebi A, et al. Invariant amino acids essential for decoding function of polypeptide release factor eRF1[J]. Nucleic Acids Res, 2005, 33(19): 6418-6425.
  • 7Sergey L, Petr K, Laure B, et al. Different modes of stop codon restriction by the Stylonychia and Paramecium eRF1 translation termination factors[J]. PNAS, 2007, 104(26): 10524-10529.
  • 8Kodama H, ho K, Nakamura Y. The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae[J]. Genes to Cells, 2007, 12: 639-650.
  • 9Vladimir A M, Artem V K, Irina Y P, et al. Termination of translation in eukary, qtes is mediated by the quaternary eRF1-eRF3-GTP-Mg^2+ complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct[J]. Nucleic Acids Research, 2006, 34(14): 3947-3954.
  • 10He F, Brown A and Jacobson'A. Upflp, Nmd2p and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway[J]. Mol Cell Biol, 1997, 17: 1580-1594.
东北农业大学学报
2008年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部