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诺卡菌属菌株04-5195发酵液中活性成分04-5195A的分离、纯化与结构鉴定 被引量：3

Extraction,purification and structure identification of the active component from fermentation broth of Nocardia sp. 04-5195
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摘要 目的分离、纯化与鉴定诺卡菌属菌株04-5195发酵液中的活性成分。方法采用多种层析方法进行活性成分分离,并通过FAB-MS、1H-NMR和13C-NMR测定对其结构进行鉴定。结果分离到一个主要组分04-5195A,其结构鉴定为3,4-二氢-8-羟基异香豆素衍生物。结论主要组分04-5195A与文献的报道的amicoumacin B相同。 Objective To identify sp. 04-5195. Methods Column c the active component extracted from fermentation broth of Nocardia omatography was used for purification; FAB-MS, ^1H-NMR and ^13C-NMR were applied to identify structure of the active component. Result Compound 04-5195-A was isolated and was structurally identified as a derivate of 3,4-dihydro-8-hydroxy isocoumarin. Conclusion The 04-5195A is identical with amicoumacin B.
作者 杨兆勇 张志斐 解云英 孙薇 司书毅 张月琴
机构地区 中国医学科学院医药生物技术研究所 华北煤炭医学院
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2008年第6期325-327,共3页 Chinese Journal of Antibiotics
基金 国家自然基金资助项目(30100225)
关键词 诺卡菌 Amicoumacin B 04-5195A 异香豆素类 结构鉴定 Nocardia Amicoumacin B 04-5195A Isocoumarin Structure identification
分类号 R977.1 [医药卫生—药品]
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参考文献7

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二级参考文献6

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共引文献2

同被引文献63

  • 1王强,彭开松,严兵,屠利民,涂健,祁克宗.枯草芽孢杆菌源抗生素研究进展[J].动物医学进展,2010,31(9):97-101. 被引量：18
  • 2黄武仁,朱昌雄,杨秀芬,杨怀文,许鸿章,解云英,简恒.嗜线虫致病杆菌代谢产物CB6-1的分离、纯化与结构鉴定[J].中国抗生素杂志,2005,30(9):513-515. 被引量：9
  • 3黄武仁,杨秀芬,杨怀文,刘峥,袁京京.嗜线虫致病杆菌的抑菌物质及抑菌活性[J].天然产物研究与开发,2006,18(1):25-28. 被引量：9
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中国抗生素杂志
2008年 第6期

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