血管重建术后再狭窄的防治现状

Status Quo in Prevention and Treatment for Restenosis after Reconstructive Vascular Operation

目的了解血管重建术后再狭窄的各种防治手段。方法对有关国内、外血管重建术后再狭窄防治方法的文献进行综述。结果血管再狭窄的防治手段包括基因治疗、药物治疗、血管外支架和物理治疗等。基因治疗的方法包括转染能抑制血管平滑肌细胞增殖的基因和利用反义核酸技术或RNA干扰技术使能促进血管平滑肌细胞增殖的基因失活。结论各种防治方法各有优、缺点,有些还存在争议。随着分子生物学技术的发展,基因治疗将会成为防治血管再狭窄的最有效手段。

Objective To review various kinds of therapeutic methods for restenosis after reconstructive vascular operation. Methods The literatures about prevention and treatment for restenosis after reconstructive vascular operation were reviewed. Results Therapeutic methods for vascular restenosis include gene therapy, drug treatment, placing external stent around the vein graft and physical therapy. The methods of gene therapy include transferring genes that inhibit the proliferation of vascular smooth muscle cell （VSMC） and inactivating genes that promote the proliferation of VSMC through technology of antisensenucleic acids or RNA interference. Conclusion Current treatment for restenosis after reconstructive varscular operation have both advantages and disadvantages, some of which are still being disputed. With the development of the technology of molecular biology, gene therapy would be the most effective therapy method for vascular restenosis.