胎儿铅暴露对婴儿情绪发育的影响

Effects of prenatal lead exposure on infant emotional development

目的研究宫内铅暴露对日后婴幼儿情绪发育的影响,探讨导致婴儿情绪障碍的原因。方法选取足月新生儿脐带血测量血铅,并按照脐血铅含量分3组,A组为血铅0￣200μg/L,B组为血铅￣500μg/L,C组为血铅>500μg/L。追踪观察这3组新生儿9个月时的情绪发育情况,同时做关于情绪和社会适应能力(ASQ)的问卷调查,比较不同脐血铅对婴幼儿情绪发育的影响。结果3组间的ASQ分值差异有统计学意义(P<0.01),且随着血铅值的升高,ASQ分值也越高(分值和情绪发育呈负相关)。结论胎儿铅暴露在一定程度上可以造成日后婴幼儿情绪发育和社会适应能力的异常。

Objective To study the effects of prenatal lead exposure on infant emotional development and to investigate the causes of infant emotional disorders. Methods A cohort of mature newborns was assigned to three groups based on levels of lead in the cord blood, namely, group A （0-200μg/d）, group B （200-500 μg/d） and group C （〉50μg/d）. The three groups were followed up for their emotional development up to nine months of life when they were assessed using Ages ＆ Stages Questionnaire - Social Emotional （ASQ-SE）. Effects on emotional development in relation to lead levels in cord blood were compared among these babies. Results The scores of ASQ were significantly different among the three groups （P〈0.01）, with higher levels of blood lead linked to higher scores by ASQ. A negative correlation was found between ASQ scores and status of emotional development. Conclusion Prenatal exposure to lead would result in impaired emotional development and social adaptation later in life.