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Toll样受体4介导的革兰阴性细菌免疫应答研究进展 被引量：7

Study Progress of Gram-Negative Bacterial Immune Response Mediated by Toll-Like Receptor 4
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摘要 Toll样受体4(TLR4)是机体重要的天然免疫受体分子之一。革兰阴性细菌内毒素通过激活TLR4,启动信号传导,介导天然免疫和炎性反应。TLR4表达缺陷或反应低下可导致机体对革兰阴性细菌易感,过度的炎性反应则可引起全身炎性反应综合征甚至内毒素性休克的发生,通过对TLR4的深入研究,可为临床感染性疾病的治疗提供新的思路。
作者 刘会领 陈敏 陈昌辉
机构地区 四川省人民医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2008年第10期790-793,共4页 Journal of Applied Clinical Pediatrics
基金 四川省科技厅科研基金项目资助(05JY029-054-2)
关键词 TOLL样受体4 革兰阴性细菌 免疫 脂多糖
分类号 R392 [医药卫生—免疫学]
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参考文献31

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实用儿科临床杂志
2008年 第10期

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