微波促进N-噁唑啉苯基马来酰亚胺的合成

Synthesis of N-Phenyl Maleimides Containing Bulky Oxazoline Group Assisted by Microwave Radiation

以靛红酸酐、2-氨基醇和马来酸酐为原料合成了两种N-噁唑啉苯基取代马来酰亚胺衍生物。以固相微波合成技术着重考察了催化剂用量、反应时间和微波功率等反应条件对酰胺酸环合反应的影响。发现以硅藻土负载的固相微波合成能够高效地实现酰胺酸的无溶剂环合反应。在最佳反应条件下产物收率可达80%以上。且应用核磁共振、红外光谱及元素分析对产物进行了表征。

[o- （4-alkyloxazol-2-yl） phenyl] maleimides were synthesized from isatoic anhydride, 2-aminoalcohol and maleic anhydride. In the key step of preparation - the cyclodehydration of maleamic acid assisted by microwave radiation useddiatomite as carrier, various reaction parameters including catalyst, time and power, were examined in detail. Under optimum conditions, the maleimides-based derivatives containing bulky oxazoline groups were obtained in yields more than 80% within few minutes without reaction solvents. The resulting compounds were characterized by ^1H NMR, FTIR and elemental analysis.