飞行员血清胆红素及MDA-LDL与动脉粥样硬化水平相关性分析

Relationship between Atherosclerosis and Serum Bilirubin Concentrations and MDA-LDL on Airplane Pilots

目的通过TBIL，DBIL，IBIL，MDA—LDL及飞行员动脉粥样硬化程度的检测，评价TBIL，DBIL，IBIL，MDA—LDL与动脉粥样硬化程度的相关性。方法495名飞行员，年龄22～43岁；对照组为地勤体检人员40名，年龄25～46岁健康，禁食12h，空腹早8点抽取静脉血用KHC。法检测总胆红素（TBIL）、直接胆红素（DBIL）和间接胆红素（IBIL）；用ELISA双抗体夹心法检测丙二酰二醛修饰的低密度脂蛋白（MDA—LDL）。依据颈动脉超声检查颈动脉窦部粥样宽块厚度的结果，将动脉粥样硬化的程度分为0，1，2，3级。结果飞行员动脉粥样硬化患病率为21．2％。动脉粥样硬化的不同程度与TBIL，DBIL，IBIL呈负相关（r=-0．257，P〈0．001；r=-0．341，P〈0．001，r=-0．316，P％0．001），与MDA—LDL呈正相关（r=0．114，P〈0．05）；MDA—LDL与TBIL，DBIL，IBIL呈负相关（r=-0．216，P〈0．01，r=-0．175，P〈0．05，r=201．P〈0．01）。结论飞行员的MDA—LDL，TBIL，DBIL，IBIL不但是诱发动脉粥样硬化的一个临床危险因素，而且可能还参与了动脉粥样硬化的发生和发展过程。

Objective To study the correlation between the concentration of TBil,DBil,IBil and MDA-LDL in pilots serum and the degree of atherosclerosis of pilots. Methods The blood samples of pilots and control group were collected;the concentration of TBil,DBil,and IBil were detected by SHC3 method and MDA-LDL was detected by ELISA. The thickness of atherosclerosis block of carotid was detected by ultrasonic. Basis on the ultrasonic result,the atherosclerosis degree was divided into 4 grade （0,1,2,3）,all data were be analyzed by SPSS 10. 0 software. Results About 21.4% pilots suffered from atherosclerosis. The correlativity between the concentration of TBil ,DBil ,IBil and MDA-LDL in pilots serum and the degree of atherosclerosis of pilots were obviously （r=- 0. 257,-0. 341,-0. 316,0. 114）. Conclusion The high level of TBil, DBil, IBil and MDA-LDL in pilots serum maybe increase the risk of suffering from atherosclerosis and TBil ,DBil,IBil and MDA-LDL may be involve in pathogenesis of atherosclerosis.