胱抑素C测定在肾脏疾病诊断中的临床应用

Clinical Application of Cystain C Mensuration Used in Kidney Disease Diagnosis

目的探讨肾功能损害及肾损伤时血清胱抑素C(cystain C)作为早期敏感标志物对临床诊断的价值。方法采用透射比浊法测定血清cystain C的浓度,同时测定血清肌酐(Scr)、尿素氮(BUN)、肌酐清除率(Ccr)。结果血清cystain C在对照组、肾功能不全组、肾衰组的值分别为0.63±0.41,2.59±1.32,7.13±1.68mg/L。结论血清cystain C是反应肾脏损伤的敏感指标,可以替代操作繁琐的内生肌酐清除率来判断肾小球滤过功能。应用cystain C评价异常肾小球滤过率有广泛的前景。

Objective To discuss the value of using serum cystain C as an early sensitive mark when kidney functional impaired and kidney damnified. Methods Using transmission turbidity method to test the density of serum cystain C,serum creatinine （Scr） ,BUN and Ccr. Results The value of serum in contrast group,incomplet kidney function group and kidney weakness group were：0. 63±0. 41,2.59±1.32 and 7.13±1.68 mg/L respectively. Conclusion Serum cystain C is a sensitive mark to reflect the kidney impairment,it could be used to judge the filtration function of glomerular instead of the tedious endogenous creatinine clearane（Ccr）method. Using cystain C to evaluate the abnormal glomerular filtraion rate（GFR ）has a wide prospect.