神经节细胞对暗视阈值反应的研究

THE EFFECT OF THE RETINAL GANGLION CELL ON THE ORIGIN OF THE CAT AND HUMAN SCOTOPIC THRESHOLD RESPONSE

目的：探讨神经节细胞在暗视阈值反应（ｓｃｏｔｏｐｉｃｔｈｒｅｓｈｏｌｄｒｅｓｐｏｎｓｅ，ＳＴＲ）形成中的作用。方法：记录６只正常猫眼和４只视网膜光凝猫眼的ＳＴＲ。倍频ＹＡＧ固体激光环绕视乳头周围行视网膜光凝，光凝后分别于４、８和１６周记录闪光视觉诱发电位（ＦＶＥＰ）和系列光暗适应视网膜电图（ＥＲＧ），并于光凝后８、１６周取视网膜作光镜和透射电镜观察。记录１８名正常人和６例视神经萎缩患者的ＦＶＥＰ、系列光暗适应ＥＲＧ和ＳＴＲ。结果：光镜和透射电镜观察证实，视网膜光凝后神经节细胞逆行性萎缩。光凝后猫眼ＦＶＥＰ消失、ＳＴＲ在正常范围。视神经萎缩患者ＦＶＥＰ消失，ＳＴＲ和正常对照组无显著性差异。结论：神经节细胞在ＳＴＲ形成过程中不起作用，ＳＴＲ的细胞起源和神经节细胞无关。

PURPOSE:To investigate the effect of the retinal ganglion cell on the origin of the scotopic threshold response(STR)of the cat and human electroretinogram.METHODS:An optic atrophy model was established in cats with retinal photocoagulation around the optic disc.The STR and flash visual evoked potentials(FVEP)were recorded from 18 cases(24 eyes)of normal human,6 cases of the optic atrophy patients,6 cases of normal cats and 4 cases of retinal photocoagulating cats in 4, 8 and 16 weeks after retinal photocoagulation.In addition,ganglion cells were observated in 8 and 16 weeks after retinal photocoagulation using light and electron microscopes.RESULTS:The pathologic changes after retinal photocoagulation verify secondary atrophy of ganglion cells.STR was normal and FVEP was not recorded in cats of retinal photocoagulation and patients with optic atrophy.CONCLUSION:Retinal ganglion cell loss does not abolish the cat and human STR.There is no effect of ganglion cell on the origin of STR.