HRE对转染VEGF165基因表达的调控作用

Action of HRE to control the expression of transferred VEGF 165 gene in the Coronary Heart Disease

血管内皮生长因子是一种内皮细胞特异性的促有丝分裂原，能与特异性受体结合，促进内皮细胞增殖、加速新生血管形成和增强血管通透性。缺氧反映元件与低氧诱导因子1结合来调控血管内皮生长凼子的表达。

Vascular endothelial growth factor （VEGF） as a specific endothelial cell mitogcn, with the specific receptor binding and promoting endothelial cell proliferation, angiogenesis, and accelerated increase vascular pcrmeability.Hypoxic response elemcnt（HRE）with H ypoxia inducible factor-1 （HIF-1） to control the expression of VEGF.