益肾活血解毒法治疗慢性肾小球肾炎40例临床观察

Clinic Observation on Treatment of 40 Chronic Glomerulonephritis Cases with Method of Kidney Benefiting, Blood Activation and Toxin Removal

目的:观察益肾活血解毒法治疗CGN的临床疗效和作用机理。方法:将临床确诊的CGN80例随机分为治疗组和对照组各40例。治疗组用益肾活血解毒法治疗,拟定慢肾益泰胶囊和慢肾康复汤口服。对照组口服肾炎四味片和六味地黄丸。结果:治疗组40例总有效率92.5%,其中完全和基本缓解31例(77.5%);对照组40例总有效率67.5%,其中完全和基本缓解20例(50.0%),两组比较有显著性差异(P<0.05)。结论:益肾活血解毒法治疗CGN的作用机理可能是通过稳定内环境,改善肾小球毛细血管滤过膜的病理损害,促使肾脏病变组织的修复,同时提高血浆白蛋白和降低胆固醇而获取临床疗效。

Objective：to observe clinical effect and mechanism on the method of kidney benefiting, blood activation and toxin removal for Chronic Glomerulonephritis （CGN）. Method：80 confirmed CGN patients were randomly and equally divided to treated group and control group. The treated group was given Yitai CGN Capsule and CGN rehabilitation decoction orally under guidance of the method. The control group was orally taken glomerulonephritis Siwei Tablets and Liuwei Dihuang Tablets, Results ： Of the treated group, total ef- fective rate was 92.5% and 31 cases were of complete or preliminary remission （77.5%） ; total effective rate of the control group was 67.5% , and 20 cases were of complete or preliminary remission （50%）. Two groups were significantly different in this regard （P 〈 0. 05 ）, Conclusion：To achieve the therapeutic effect in terms of renal tissue repair, Haemproteins rise and cholesterin reduction, the method may have worked on stability of internal environment and reduction of pathological damage to filter membrane of glomerular capillary.