人早期胚胎活性因子抗肿瘤作用初步研究

PRIMARY RESEARCH INTO THE ANTINEOPLASTUC EFFECT IF ACTIVE AGENTS OF EARLY HUMAN EMBRYO.

用制备的人早期胚胎活性因子（简称ＲＰ因子）进行抗肿瘤作用的实验研究，结果体外传代细胞培养ＲＰ因子对Ｈｅｐ－２、Ｈｅｌａ细胞有显著性抑杀作用，对正常２ＢＳ细胞无抑杀作用；可诱导ＬＡＫ细胞，激活ＮＫ细胞，对Ｙａｃ－１瘤细胞、Ｒａｊｉ淋巴瘤细胞、腹水瘤Ｓ１８０细胞的杀伤效果与ＩＬ—２相关似；可显著抑制小鼠肝癌实体瘤的增长，抑瘤率＞３０％以上。显示ＲＰ因子抗肿瘤和增强机体免疫功能的作用。

xperimental research into the antineoplastic effects was carried out with prepared active agents of early humen embryo.The result showed that RP agents cultured with extrinsic reproductive cells had obvious effects of inhibition and kill to hep-2 hela cells,and have no inhibition and kill effects to normal 2BS cells.They can induce LAK cells and activate NK cells;and their effects of killing Yac-1 oncocytes,Raji lymphomatous cells and ascites sarcoma cells are similare to that of IL-2.RP agents can inhibit the growth of solid liver carcinoma of mice and the inhibiting rate to tumor is above 30%.The above results show that RP agents have antitumor effects and can improve the immunologic function of the body.