A retrospective study on estrogen or contraceptives in the treatment of dysfunctional uterine bleeding in adolescent patients

Objective: To investigate the clinical efficacy of estrogen or contraceptives in the treatment of acute bleeding of dysfunctional uterine bleeding (DUB) in adolescent patients and the optimal starting dosage of drugs.Methods: The clinical records of 106 girls who with DUB and moderate or severe anemia from February 1990 to July 2005 were analyzed retrospectively.Results: All 106 patients received hormonal therapy. 56 patients were treated with estradiol benzoate(E2), 30 patients with conjugated equine estrogen(CEE) and 20 patients with combined oral contraceptives (COCs). The rates for rapidly controlling bleeding and for rapidly stopping bleeding in E2 group were higher than those in CEE group ,but similar to those in COCs group. The days for controlling and completely stopping bleeding were not significantly different between the starting dosages (≤8 mg/d and >8 mg/d) of E2 groups, and also there were no statistical difference between the starting dosages (<7.5 mg/d and ≥7.5 mg/d) of CEE groups, but during the treatment the rate of increasing the dosage in <7.5 mg/d group was higher than that of ≥7.5 mg/d group(40% vs. 5%),while there were no statistical difference between the starting dosages (≤3 pills/d and >3 pills/d) of COCs groups. Conclusions: The clinical efficiency of E2 treatment on DUB in adolescent patients is similar to that of COCs. And the efficacies of treatment of DUB with E2, CEE and COCs in the different dosages are similar.

Objective： To investigate the clinical efficacy of estrogen or contraceptives in the treatment of acute bleeding of dysfunctional uterine bleeding （DUB） in adolescent patients and the optimal starting dosage of drugs. Methods： The clinical records of 106 girls who with DUB and moderate or severe anemia from February 1990 to July 2005 were analyzed retrospectively. Results： All 106 patients received hormonal therapy. 56 patients were treated with estradiol benzoate（Ez）, 30 patients with conjugated equine estrogen （CEE） and 20 patients with combined oral contraceptives （COCs）. The rates for rapidly controlling bleeding and for rapidly stopping bleeding in Ez group were higher than those in CEE group ,but similar to those in COCs group. The days for controlling and completely stopping bleeding were not significantly different between the starting dosages （≥48 mg/d and 〉8 mg/d） of E2 groups, and also there were no statistical difference between the starting dosages （〈7.5 mg/d and ≥7.5 mg/d） of CEE groups, but during the treatment the rate of increasing the dosage in 〈7.5 mg/d group was higher than that of ≥7.5 mg/d group（40% vs. 5%）,while there were no statistical difference between the starting dosages （≤3 pills/d and 〉 3 pills/d） of COCs groups. Conclusions： The clinical efficiency of E2 treatment on DUB in adolescent patients is similar to that of COCs. And the efficacies of treatment of DUB with E2 CEE and COCs in the different dosages are similar.