高山红景天多糖对病毒感染大鼠心肌细胞的抑制作用

Inhibition of polysaccharde extracted from rhodiola sachalinensis A. bor on myocardial cells infected by cox B3 virus

目的：观察高山红景天多糖对柯萨奇Ｂ３病毒感染ＳＤ大鼠心肌细胞的抑制作用。方法：采用原代培养乳鼠心肌细胞的方法，建立实验性病毒性心肌炎模型。结果：高山红景天多糖能明显的抑制体外培养心肌细胞在受到柯萨奇Ｂ３病毒感染后导致的心肌酶释放；显著降低病毒在心肌细胞中的增殖量；其半数有效抑制浓度为１５０ｍｇ·Ｌ－１；有效浓度平均抑制率为７１．３％。结论：高山红景天多糖对在ＳＤ大鼠心肌细胞内增殖的柯萨奇Ｂ３病毒具有一定的抑制作用。

AIM: To observe the inhibitive effect of polysaccharide extracted from Rhodiola Sachalinensis A. Bor on myocardial cells infected by cox B3 virus. METHOD: To establish an experimental model of viral myocarditis through the culture of cardiac cells of newborn SD rats. RESULTS: The polysaccharide could inhibit the release of enzymes from myocardial cells which were infected by coxsackie B3 virus in vitro; and decrease obviously the reproduction of virus in myocardial cells; the half inhibitive concentration was 150 mg·L-1; the average effective inhibiting rate was 713%. CONCLUSION: The polysaccharide extracted from Rhodiola Sachalinensis A. Bor could inhibit the reproduction of coxsackie B3 virus in myocardial cells of SD rats.