5种抗氟复方当归散对氟排泄及组织氟含量的影响

EFFECTS OF FIVE FINDS ANTI-FLUORINE COMPOUND DANGGUI POWDER ON FLUORINE EXCRETION AND TISSUE FLUORINE CONTERTS IN CHRONIC FLUOROSIS RATS

根据单味中药的药理作用及药味增减理论,对前期研究的抗氟复方当归散基础方加以改进,分别拟定出抗氟复方当归散Ⅰ、Ⅱ、Ⅲ和Ⅳ,并分别灌服给予氟中毒大鼠,以观察它们对氟中毒大鼠氟排泄和组织氟含量的影响。阴性对照组自由饮自来水,其余各组自由饮含氟100mg/L的自来水,并按0.1g/kg给予各复方当归散。在试验期,观察各组大鼠氟斑牙发生情况,跟踪检测尿氟和粪氟含量。试验结束时,测定各组大鼠骨、血浆、肝和肾氟含量。结果表明,阳性对照组已成功复制出慢性氟中毒模型;在各给药组中,给予抗氟复方当归散Ⅲ组的氟排泄量较多,且明显减少组织氟含量,具有相对较强的排氟效应。

Based on Chinese medicine theory and single herb＇s pharmacological action, the basic anti-fluorine compound DANGGUI powder were improved and four other compound DANGGUI powder Ⅰ ,Ⅱ , Ⅲ and Ⅳ were designed for comparative studying of their anti-fluorine pharmacological effects. All the Wistar rats were assigned to 7 groups, which are negative control group, positive control group and 5 other therapeutic groups, respectively. The negative control group was drunk with normal tap water, the others were drunk with water containing of 100mg/L fluorine. Except the rats in 2 control groups all other rats were administered 5 different kinds of antifluorine compound DANGGUI powder simultaneously by per os with dosage of 0.1 g/kg, respectively. The dental damage was inspected seriously and the contents of fluorine in urine, dung, plasma, liver, kidney and bone were determined during the experiment. The experimental results showed that all of the anti-fluorine compound DANGGUI powders can obviously alleviate the dental damage and increase the excretion of fluorine from dung and also can reduce the fluorine contents in some tissues. Therefore, the anti-fluorine compound DANGGUI powders have excretive effects on fluorine.