不同人群庚型肝炎病毒感染状况分析

Primary analysis of the situation of hepatitis G virus infection in different groups of people

为了解不同人群庚型肝炎病毒（ＨＧＶ）感染状况，采用优化的ＨＧＶＮＳ５区两条合成肽为抗原，建立间接酶联免疫吸附试验（ＥＬＩＳＡ），检测了１２０９例不同人群血清中抗－ＨＧＶＩｇＧ，总阳性率为３．８％，其中非Ａ～Ｅ型肝炎患者抗－ＨＧＶＩｇＧ阳性率最高，为２０．５％，明显高于自然人群的０．８％和其它肝炎患者（Ａ～Ｅ型）的３．３％，丙型肝炎患者中抗－ＨＧＶＩｇＧ阳性率亦较高，为８．０％。职业献血员抗－ＨＧＶＩｇＧ阳性率３．４％高于义务献血员０．０％。性病患者阳性率为３．６％，有静脉吸毒史的ＨＩＶ感染者阳性率亦较高，为８．０％。结果表明，ＨＧＶ在我国有较高的感染率；ＨＧＶ可能为非Ａ～Ｅ型肝炎的重要致病因子；职业献血员和有血液接触史者ＨＧＶ感染率较高。

In order to investigate the situation of hepatitis G virus (HGV) infection among different groups of people, two selfselected peptides from HGV NS5 were used to develop an indirect ELISA for antiHGV IgG detection. 1209 sera from different peoples were detected and the positive rate of antiHGV IgG was (3.8%). Among these groups the group of non AE hepatitis had the highest antiHGV positive rate (20.5%), higher than that in the groups of natural people (0.8%) and other hepatitis patients (3.3%), the difference was significant. The antiHGV IgG positive rate in the group of HC patients 8.0% was higher than that in other hepatitis AE patients, the positive rate (8.0%) in paid donors was higher than that in voluntary donors (0%), and that in groups with venereal diseases and HIV infection were 3.6% and 8.0%, respectively. The results suggested that there has higher rate of HGV infection in our country; HGV is the important factor causing non AE, the paid donors is the dangerous group, they should be strictly screened, and the people with transfusion have higher rate of HGV infection. Since there is different rate of HGV infection in different human population so it is important to study further the epidemiological characteristics of HGV for its prevention.