幽门螺杆菌感染患者胃窦粘膜IL-6和TNF-α水平变化及其意义

Interleukin-6 and Tumor Necrosis Factor-a Activities in Patients with Helicobacter Pylori Infection

检测幽门螺杆菌（HP）感染胃炎患者胃窦粘膜体外培养上清液中白细胞介素-6（IL-6）活性和肿瘤坏死因子（TNF-α）的含量。结果表明:Hp阳性胃炎患者胃窦粘膜IL-6活性和TNF-α含量均明显高于Hp阴性患者和正常对照组;合并活动性胃炎患者胃窦部TNF-α含量也明显高于非活动性胃炎,但两者胃窦部IL-6活性却没有明显的差异。

The activities of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in human antral mucosa of patients with Helicobacter pylori (Hp) infection were investigated by bioactivity assay and radioimmunoassay. The results showed that antral IL-6 and TNF-α activities in patients with Hp infection were significantly greater than those in patients without Hp infection and normal controls. TNF-α level was significantly higher in patients with active gastritis than in those with inactive gastritis. In contrast, IL-6 activity were raised in both active and inactive gastritis.