骨代谢与铁代谢相关研究进展

Study Progress about Correlation between Bone Metabolism and Iron Metabolism

对骨代谢的研究是骨科领域的一项重要课题,过去数十年中对骨代谢的研究主要侧重于骨代谢与钙代谢相关性的研究。铁调素是一种能调节血铁水平的小分子肽类激素。自2001年发现铁调素之后,铁代谢的研究取得了突破性进展,骨代谢与铁代谢相关性的研究也随之引起了越来越多的关注。一系列的研究表明,骨代谢与铁代谢之间存在着密切的关系:铁超载可致骨质疏松,铁不足又使骨密度下降。

Research on bone metabolism is an important topic in the orthopedic field. In the past decades, the studies bout bone metabolism was focused on the dependability between bone metabolism and calcium metabolism. Hepcidin was a newly discovered micromolecular peptide hormone. The study about iron metabolism had maken a great breakthrough, and the dependability beteen bone metabolism and iron metabolism is also attracting more attention. A series of studies showed that bone metabolism has close relationship with iron metabolism, that is,iron overloading can result in osteoporosis, and iron deficiency can result in decreased bone density.