氧化低密度脂蛋白受体基因多态性及临床意义

The Clinical Signification of the Polymorphism of the Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Gene

寻找易感基因是当今分子生物学研究的热点,遗传相关性研究和连锁分析已经找到了多个动脉粥样硬化及急性冠状动脉综合征的基因位点,血凝素样氧化低密度脂蛋白受体基因正是其中之一。多个研究证实,氧化低密度脂蛋白受体基因多态性与冠状动脉粥样硬化性心脏病、急性心肌梗死、他汀类药物的抗血小板活性和阿尔茨海默病发病之间的关系。血凝素样氧化低密度脂蛋白受体1基因多态性与冠状动脉粥样硬化性心脏病等动脉粥样硬化疾病关系的研究结果之间存在差异,二者相关性的检出有待于进一步更大规模的研究。

Exploration of susceptible gene might be a focus of current molecular biology. Genetic linkage researches have discovered several gene locations associated with atheroselerosis and acute coronary syndrome, one of which is the lectin-like oxidized low-density lipoprotein receptor-1 （ LOX-1 ）. Some researches confirmed that the correlation between oxidized low-density lipoprotein （ox-LDL）and coronary artery disease, acute myocardial infarction,the activity of Hydroxymethyl-glutaryl coenzyme A has been reported to be able to prevent blood platelet congregating and Alzheimer＇s disease. The relation of between LOX-1 and atherosclerosis such as coronary artery disease are in discuss. So. their relation should be studied in much larger scale.