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p16^(INK4A)基因与宫颈癌早期防治 被引量：2

p16^(INK4A) Gene and Earlier Prevention and Cure of Cervical Cancer
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摘要 随着分子生物学的发展,人们发现在宫颈癌的发生、发展过程中,有多种癌基因、抑癌基因及相关因子参与,其中某些基因结构、功能等都会发生变化,这些基因可以作为这一进程中的分子标志,来用于高危病例的筛选。p16INK4A是人们发现的第一个直接参与细胞周期调控的抑癌基因。它的过表达发生在宫颈癌和癌前病变阶段,可作为一种肿瘤标志物用于宫颈癌的临床筛查及诊断中。 With the development of molecular biology, it is known that many oncogenes and anti-oncogenes as well as their related factors took part in the genesis and development of cervical cancer,some genes among them had some changes in their gene structure and function ,which could be used to screen cases with high risk as molecular markers during the process of cervical cancer, pl6^INK4A is the first found anti-oncogene participating the cell cycle regulation directly. It has over expression during cervical cancer and precancerosis. So it can be used as a kind of tumor marker for the clinical screening and diagnosis of cervical cancer.
作者 武玲 宋静慧
机构地区 内蒙古医学院 内蒙古医学院第一附属医院妇产科
出处 《医学综述》 2008年第12期1805-1806,共2页 Medical Recapitulate
关键词 P16^INK4A 宫颈癌 宫颈上皮内瘤变 非典型鳞状细胞 p16^INK4A Cervical cancer Cervical intraepithelial neoplasma Atypical squamous of undermined signi cance
分类号 R711.74 [医药卫生—妇产科学] R737.33 [医药卫生—肿瘤]
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参考文献16

  • 1乐杰.妇产科学[M]5版[M].北京:人民卫生出版社,2001.129.
  • 2Klaes R, Friedrich T, Spitkovsky D, et al. Overexpres-sion of p16^INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri[J]. Int J Cancer, 2001,92 (2): 276-284.
  • 3Tringler B,Gup CJ,Singh M, et al. Evaluation of p16INK-4a and pRb expression in cervical squamous and gland-ular neoplasia [ J ]. Hum Pathol,2004,35 (6) :689-696.
  • 4Kamb A, Gruis NA, Waever-Frldhaus J, et al. A cell cycle regulator Potentially involved in genesis of many tumor types[ J]. Science, 1994,8( 1 ) :23-26.
  • 5Serrano M. A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/CDK4-[ J ], Nature, 1993, 366 (6456) :704-707.
  • 6Chinvel P, Courdi A, Gioanni J, et al. The labeling index; a prognostic factor in lead and neck carcinoma[ J]. Radiother Oncol, 1989,14 (3) :231-237.
  • 7Sano T, Oyama T, Kshiwabara K, et al, Explession status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesion [ J ]. Am J Pathol, 1998,153 (6) : 1741-1748.
  • 8Milde Langosch K, Riethdorf S, Kraus Poppinghaus A, et al. Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas[ J]. Virchows Arch,2001,439( 1 ) :55-61.
  • 9Nakao Y,Yang X,Yokoyama M,et al. Induction of p16 during immortalization by HPV16 and 18 and nor during malignant transfornation[ J ]. Br J Cancer, 1997,75 (10) : 1410-1416.
  • 10Murphy N, Ring M, Killalea AG, et al. p16 as a marker for cervical dyskarycais: CIN and CGIN in cervical biopsies and Thinprep smears[J]. J Clin Pathol,2003,56( 1 ) :56-63.

二级参考文献23

  • 1孙小蓉,李玉兰,车东媛,晏想成,凌慧芳,凃洪章,汪键.用细胞DNA定量分析方法进行宫颈癌普查的临床研究[J].诊断病理学杂志,2005,12(1):12-16. 被引量：67
  • 2Liu S, Semenciw R, Probert A, et al. Cervical cancer in Canada: changing patterns in incidence and mortality. Int J Gynecol Cancer, 2001,11:24-31.
  • 3Guidozzi F. Screening for ovarian cancer. Obstet Gynecol Surv, 1996,51:696-701.
  • 4Wright TC, Kurman RJ, Ferenczy A. Precancerous lesions of the cervix. In: Kurman RJ, ed. Blaustein′s pathology of the female genital tract. 5th ed. New York: Springer, 2002.253-324.
  • 5Munoz N, Bosch FX. The causal link between HPV and cervical cancer and its implications for prevention of cervical cancer. Bull Pan Am Health Organ, 1996,30:362-377.
  • 6B(o)cking A, Motherby H. Assessment of cervical dysplasia with DNA image cytometry. Pathologe, 1999,20:25-33.
  • 7Haroske G, Baak JP, Danielsen H, et al. Fourth updated ESACP consensus report on diagnostic DNA image cytometry. Anal Cell Pathol, 2001,23:89-95.
  • 8Grote HJ, Friedrichs N, Pomjanski N, et al. Prognostic significance of DNA cytometry in carcinoma of the uterine cervix FIGO Stage IB and II. Anal Cell pathol, 2001,23:97-105.
  • 9Hanselaar AG, B(o)cking A, Gundlach H, et al. Summary statements on quantitative cytochemistry (DNA and molecular biology): Task Force 8. Acta Cytol, 2001,45:499-501.
  • 10Bulten J, Poddighe PJ, Robben JC, et al. Interphase cytogenetic analysis of cervical intraepithelial neoplasia. Am J Pathol, 1998,152:495-503.

共引文献260

同被引文献19

  • 1牛昀,李妤,牛瑞芳,吕阿娟,傅西林.E2F-1和Rb基因表达与乳腺乳头状瘤病及导管内癌的相关性[J].中华肿瘤杂志,2004,26(5):290-293. 被引量：12
  • 2张雪宝,陆天才,李锋,潘晓琳,陶林,蒋金芳.神经生长因子及其两种受体与子宫颈原位癌的相关性研究[J].实用肿瘤杂志,2004,19(4):306-311. 被引量：16
  • 3董磊,宋张娟.宫颈鳞癌中p16、p21^(WAF1)、Rb、cyclinE蛋白的表达[J].临床与实验病理学杂志,2004,20(5):554-556. 被引量：15
  • 4Tommasina M.Early gene of human papillomaviruses//Encyclopedic Reference of cancer.Heidelberg:Springer-Veda & 2001:270.
  • 5Sano T,Oyama T,Kshiwabara K.Expression status of p16 protein is associated with human papillomavims oncogenic potential in cervical and genital lesion.Am J Pathol,1998,153:1741-1748.
  • 6Cohen SB,Graham ME,Lovrecz GO,et al.Protein composition of catalytically active human telomerase from immortal cells.Sci-ence,2007,315(5820):1850-1853.
  • 7Allen DG,White DJ,Hutchins AM,et al.Progressive genetic aberrations detected by comparative genomic hybridization in squamous cell cervical cancer.Br J Cancer,2000,83(12):1659-1663.
  • 8Heselmeyer-Haddad K,Sommerfeld KM,White N,et al.Genomic amplification of the human telomerase gene(TERC) in pap smears the development of cervical.Am J Pathol,2005,166(4):1229-1238.
  • 9Caraway NP,Khanna A,Dawlett M,et al.Gain of the 3q26 re-gion in cervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcino-ma.Gynecol Oncol,2008,110(1):37-42.
  • 10李素红.应用组织芯片检测宫颈鳞癌中高危HPV感染与P53及其相关基因蛋白的表达及意义.太原:山西医科大学,2005.

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医学综述
2008年 第12期

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