摘要
过敏性紫癜(HSP)是以全身性坏死性小血管炎为主要病理改变的疾病。临床以皮肤紫癜、关节炎、胃肠道病变以及肾脏损害为特点的综合征。紫癜性肾炎是指HSP引起的肾脏损害。临床上在HSP病程中(包括病程6个月以内)出现血尿和(或)蛋白尿即可诊断。HSP的病因不明,多认为与感染和变态反应有关。免疫功能紊乱是本病主要发病机制。本文就该病在激素、免疫抑制剂、抗血小板聚集剂、抗凝剂、血管扩张剂、抗氧化剂、中药、血浆置换和肾移植方面的治疗进展予以综述。
Henoch-Schonlein purpura （HSP） is a systemic necrotizing vasculitis as the main pathological changes of the disease, which was characterized by skin purpura, arthritis, gastrointestinal tract disease and kidney damage. Henoch-Schonlein purpura nephritis means that kidney damage was caused by HSP. Haematuria and （or） proteinufia presenting during the first 6 months course, the HSP should be diagnosed. The etiology of HSP remains unknown,which were regarded to be associated with infection and allergic reaction. Immune dysfunction is the main pathogenesis of this disease. This article reviewed the advancement in treatment of HSP in hormone, immunosuppressants, anti-platelet aggregation agents, anticoagulants, vasodilators, antioxidants, Chinese medicine, plasma replacement and renal transplantation.
出处
《医学综述》
2008年第12期1824-1826,共3页
Medical Recapitulate
关键词
儿童
紫癜性肾炎
治疗
Child
Henoch-schonlein purpura nephritis
Therapy
