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4,5-二甲基-1,3-二氧杂环戊烯-2-酮的合成 被引量：3

Synthesis of 4,5-Dimethyl-1,3-dioxolen-2-one
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摘要 该文以有机碱作为缚酸剂,研究了4-氯-4,5-二甲基-1,3-二氧杂环戊烷-2-酮(CDMDO)脱氯化氢制备4,5-二甲基-1,3-二氧杂环戊烯-2-酮(DMDO)的工艺。优化的工艺条件为:N,N-二甲基苯胺作为缚酸剂,甲苯为溶剂,反应温度110℃,CDMDO转化率70%。 The organic bases as binding agent of HCl were investigated in synthesis of 4,5-dimethyl-1, 3-dioxolen-2-one （ DMDO ） from 4-chloro-4, 5-dimethyl-1, 3-dioxolan-2-one （ CDMDO ）. Optimized reaction conditions of this technology were that N, N-dimethylaniline are used as binding agent, toluene as solvent, reaction temperature is 110 ℃. Under optimized conditions, the yield was 70%.
作者 胡来月 冯乙巳 朱玉川
机构地区 合肥工业大学化工学院
出处 《精细化工》 CAS CSCD 北大核心 2008年第6期600-602,共3页 Fine Chemicals
关键词 4 5-二甲基-1 3-二氧杂环戊烯-2-酮 缚酸剂 N N-二甲基苯胺 4,5 -dimethyl-1,3-dioxolen-2-one binding agent of HCl N, N-dimethylaniline
分类号 O626.2 [理学—有机化学]
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  • 1方利明,金艳,魏敏吉.氟喹诺酮类抗菌剂——普卢利沙星[J].中国医药导刊,2004,6(3):225-227. 被引量：20
  • 2程春生,张宝砚,李鹏,杨贺选.6,7-二氟-4-羟基-2-甲氧甲硫基-3-喹啉羧酸乙酯的合成[J].中国医药工业杂志,2004,35(8):459-460. 被引量：5
  • 3Hoshino K, Kitamura A, Morrissey I, et al. Comparison of inhibition of Escherichia coil topoisomerase Ⅳ by quinolones with DNA gyrase inhibition[J] .Antimicrob Agents Chemother,1994, 38(11) : 2623-2627.
  • 4Segawa J, Kitano M, Kazuno K, et al. Studies on pyridonecarboxylic acid. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo.4-oxo.4H- [1,3 ] thiazeto[3,2-a] quinoline-3-carboxylic acids [J]. J Med Chem, 1992,35 (25) : 4727-4738.
  • 5Kise M, Kitano M, Ozaki M, et al. Quinolinecarboxylic acid derivatives[P]. EP: 315828, 1989-05-17. (CA 1989, 111:194791n).
  • 6Itoh Y, Kato H, Koshinaka E, et al. Optically active thiazetoquinoline-3-carboxylic acid compound, method for preparation thereof and a pharmaceutical composition comprising the same[P]. EP: 465716, 1992-01-15; EP:393538, 1990-10-24. (CA 1991, 114: 143397t).
  • 7Friedrich EC, Falling SN, Lyons DE. A convenient synthesis of ethyldine iodide[J]. Synth Commun, 1975, 5 (1) : 33-36.
  • 8Sakamoto F, Ikeda S, Tsukamoto G. Studies on Prodrugs. Ⅱ.Preparation and characterization of (5-substituted 2-oxo-1,3-dioxolen-4-yl) esters of ampicillin [ J ]. Chem Pharm Bull, 1984,32(6) : 2241-2248.
  • 9Fischler H M, Heine H G, Hartmann W. Synthesis of some dialkyl-substituted vinylene carbonates and their photosensitized cycloaddition to ethylene[J]. Tetrahedron Lett, 1972, (17): 1701～1704.
  • 10池田升,武部靖,平山良一,等.4,5-二甲基-1,3-二氧杂环戊烯-2-酮的制备方法[P].JP 62-53983,1987-03-09.

共引文献43

同被引文献33

  • 1陈岚,张岩,李保国,刘哲鹏,陆伟跃,伍贻文,华泽钊.超临界流体技术制备阿莫西林缓释微囊的初探[J].中国药学杂志,2004,39(11):842-844. 被引量：5
  • 2肖旭辉.抗菌药伦氨苄西林盐酸盐合成[J].精细化工中间体,2004,34(6):35-36. 被引量：11
  • 3刘丽湘,丁著明.绿色化工原料双(三氯甲基)碳酸酯的合成和应用[J].化工技术与开发,2005,34(4):24-27. 被引量：3
  • 4韩丽,赵祥颖,刘建军.3-羟基丁酮的研究现状[J].食品与发酵工业,2006,32(10):116-118. 被引量：27
  • 5王艳艳,朱科,谭清钟,齐军彩,辛朝辉,王娜.阿莫西林结晶过程的研究[J].河北化工,2007,30(1):22-23. 被引量：6
  • 6Novagana S, Ghassempour A, Bashour Y,et al. Deter- mination of residual solvents and investigation of their effect on ampieillin trihydrate crystal structure [J].J Pharm Biomed Anal, 2005,36 (5) : 983-988.
  • 7Du Li-li,Wu Qi, Chen Chun-xiu, et al. A two-step,one- potenzymatic synthesis of ampieillin from penicillin G potassium salt[J]. J Moleeul Catal B: Enzym, 2009, 58 (1-4) : 208-211.
  • 8Carlos del Pozo, Eduardo Alonso, Fernando L6pez-Ortiz, et al. Synthesis of 1,1-dioxopenicillanoyloxymethyl-6-[-d-a- (benzylideneaminophenylacetamido)]penici-llanate and ana- logs. New intermediates in the preparation of sultamicillin[J].Tetrahedron, 2001, 57(29): 6209-6214.
  • 9Stachyra T, Levasseur P, P6chereau MC, et al. In vitro activity of the beta-laetamase inhibitor NXL104 against KPC-2 carbapenemase and enterobacteriaceae expressing KPC carbapenem-ases [J]. J Antimicrob Chemother, 2009,64(2) : 326-329.
  • 10Mugesh ATG. Zinc and antibiotic resistance- metallo-fl- lactamases and their synthetic analogues[J].Biol Inorg Chem, 2008(13): 1039-1053.

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精细化工
2008年 第6期

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