泰州市2006～2007年乙肝HBsAg携带状况和免疫监测结果分析

ANALYSIS OF THE RESULTS OF HBSAG CARRYING CONDITION AND IMMUNOLOGIC SURVEILLANCE OF PEOPLE INOCULATED WITH HEPATITIS B VACCINE IN TAIZHOU DURING 2006 TO 2007

[目的]了解泰州市乙肝免疫人群乙型肝炎病毒携带状况以及乙肝免疫效果。[方法]用系统随机抽样法在全市6个市(区)5个年龄组监测人群1660人和1组对照组人群322人,共抽取1982人,采用酶联吸附免疫试验(ELISA)检测血清中乙肝表面抗原(HBsAg)、乙肝表面抗体(抗-HBs),并用固相放射免疫方法标化ELISA检测结果。[结果]泰州市﹤1岁、1～2岁、3～4岁、5～6岁、7～14岁5个年龄组人群HBsAg阳性率平均为1.45%,抗-HBs阳性率平均为68.31%。随年龄组增加,抗-HBs阳性率呈下降趋势(χ=50.40,P﹤0.01)。不同市(区)监测人群抗-2HBs阳性率存在差异(χ=97.44,P﹤0.01),海陵区抗-HBs阳性率(87.87%)是高港区(55.41%)的1.6倍。免疫规2划实施后人群乙肝疫苗全程免疫接种率、HBsAg阳性率和抗-HBs阳性率分别为99.16%、1.45%和68.31%,免疫规划实施前的14～19岁人群分别为98.45%、3.73%和50.60%,HBsAg阳性率和抗-HBs阳性率在两组人群中均存在差异(P﹤0.01)。[结论]泰州市5个年龄组监测人群HBsAg阳性率平均为1.45%(0.00%～2.65%),14岁以下人群抗-HBs阳性率随年龄组升高而下降(83.95%～57.66%),不同市(区)人群抗-HBs阳性率存在差异,乙肝免疫规划的实施能有效降低人群HBsAg携带率和提高抗-HBs阳性率。

[Objective] To investigate the HBsAg carrying condition and immunolongic surveillance of hepatitis B vaccine among people inoculated with hepatitis B vaccine in Taizhou. [Methods] 1660 participants at different age group in six cities and 322 controls were collected by systematic random sampling. The HBsAg and anfi-HBs in serum were detected with enzyme hnked immunosorbent assay （ELISA）, and the detective results of ELISA were standardized by radio-immunoassay （RIA） . [ResultS] The average positive rate of HBsAg for the five age groups was 1.45% （the age groups were at the range of 0 to 1 years old, 1 to 2 years old, 3 to 4 years old, 5 to 6 years old and 7 to 14 years old）. The average positive rate of anti-HBs was 68.31%. The positive rate of anti-HBs showed decreased trend with tile increasing of age （x^2= 50.40, P 〈 0.01 ）. The positive rate of anti-HBs revealed significantly difference among different population monitored （x^2= 97.44, P 〈 0.01 ）. The positive rate of anti-HBs in Hailing district ;vas 1.6 times as mt,ch as that in Gaoguang district. After implementing the universal immunity program, the inoculation rate of hepatitis B vaccine and the positive rate of HBsAg and anti-HBs were 99.16%, 1.45% and 68.31%, respectively. Before implementing the universal immunity program, the inoculation rate of hepatitis B vaccine and the positive rate of HBsAg and anti-HBs for people at the age of 14 to 19 years were 98.45%, 3.73% （P 〈 0.01） and 50.60% （P〈 0.01 ）. Tile positive rate of HBsAg and anti-HBs showed significant difference between people inculated and controls. [ Conclusion] The average rate of HBsAg of five age groups monitored was 1.45% （0.00%-2.65%）, the positive rate of anti-HBs for people below 14 years old decreased with the increasing of age （83.95%-57.66%）. Positive rate of anti-HBs showed significant difference in different cities （districts）, Implementing universal immunity program could effectively decrease the carrying rate of HBsAg and decrease the positive rate of anti-HBs.