摘要
[目的]了解四川省吸毒人员乙型肝炎流行现状以及乙肝疫苗免疫效果,为制定策略提供依据。[方法]2005年在成都市、南充市、遂宁市戒毒所内随机选取既往未接种过乙肝疫苗的吸毒人员665名为研究对象。用酶联免疫吸附试验(ELISA)对HBsAg、抗-HBs和抗-HBc3项指标进行初筛,用固相放射免疫法(SPRIA)复核3项指标全阴者,用20μg乙肝疫苗按0、1、2程序接种,1月后采血,检测抗-HBs水平。[结果]四川省吸毒人群乙肝病毒(HBV)总感染率为90.52%,男性90.40%,女性90.97%,男女无统计学差异;吸毒人员乙肝感染标志物HBsAg,抗-HBs和抗-HBc的流行率分别为26.45%,45.86%和35.34%;静脉吸毒者(IDU)HBV总感染率高于口吸者。接种乙肝疫苗后,抗-HBs阳转率为86.96%,抗-HBs几何平均滴度(GMT)为159.39mIU/ml。[结论]四川省吸毒人群HBV总感染率高于全人群,IDU是感染乙肝的高危人群。对吸毒人群进行乙肝疫苗接种效果良好。
[Objective] To investigate the immune effect of HBV vaccine and prevalence status of HBV among drug users in Sichuan, so as to provide basis for formulating strategies. [Methods] 665 drug users who have never injected HBV vaccine were randomly selected in drug-relief institutions of Chengdu, Suining and Nanchong. HBsAg, Anti-HBs and Anti-HBc were preliminary screening by using enzyme linked immunosorbent assay （ELISA）, and patients with the three indexes to be negative re-detected by solid phase radioinmunoassay were collected to vaccinate 20μg HBV vaccine according to 0, 1 and 2 procedure, followed by detection of anti-HBs after vaccine for a month. [ Results] The total infection rate of HBV for dnug users ;vas 90.52%, and for male and female were 90.40% and 90.97%, respectively, no significantly difference did not found between them. The prevalence of HBV infection marks including HBsAg, Anti-HBs and Anti-HBc were 26.45%, 45.86% and 35.34%, respectively. The total infection rate of HBV in IDU was significantly higher than that in oral drug users （x^2 = 5.668 4, P 〈 0.05）. After irmnunization of the HBV vaccine, the seroconversion rate of anti-HBs were 86.96%, and the geometric mean titer （GMT） of anti-HBs was 159.39mIU/mL. [Conclusion] The total infection rate of HBV in drug users is significandy higher than that in the whole population of Sichuan. IDU are the high risk people to infect HBV. The effect of immunization of HBV vaccine in drug users showed to be favorable.
出处
《现代预防医学》
CAS
北大核心
2008年第12期2337-2338,2341,共3页
Modern Preventive Medicine
