大气中可吸入颗粒物对人体免疫学指标的影响

Effect of PM_(10) on human immunological parameters

目的:探讨可吸入颗粒物(PM10)对人体免疫学指标的影响。方法:根据河南省环境保护局提供的2002年至2004年大气PM10监测资料,选定PM10污染区和对照区,随机选择2地区成年居民各90名,采用放射免疫法测定血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)水平;采用ELISA方法测量2地区居民血清干扰素-γ(IFN-γ)水平。结果:PM10污染区居民血清IL-6((446.52±59.80)ng/L)水平高于对照区((56.34±9.13)ng/L)(P<0.05);污染区居民血清IL-8((0.31±0.17)μg/L)水平高于对照区((0.09±0.03)μg/L)(P<0.05);污染区居民血清TNF((0.46±0.34)μg/L)水平高于对照区((0.16±0.08)μg/L)(P<0.05);污染区居民血清IFN-γ((18.65±1.83)ng/L)水平低于对照区((20.37±0.86)ng/L)(P<0.05)。结论:PM10可对暴露人群机体免疫系统产生影响。

Aim ： To study the effect of PM10 on human immunological parameters. Methods ：Selecting the polluted area and the control area based on the monitoring data of PM10 from year 2002 to 2004 by Henan Environmental Protection Bureau. A total of 180 residents were chosen equally from these two areas. The interleukin-6 （IL-6） , interleukin-8 （IL-8） and tumor necrosis factor（TNF） levels in serum from the 180 residents were determined using radio-immunity. The interferon-γ（INF-γ） level in serum from the 180 residents was determined using ELISA. Results： The IL-6 level in serum from the inhabitant of polluted area （ （446.52 ±59.80） ng/L） was higher than that from the control area（ （56.34 ±9.13） ng/ L） （P 〈0.05） ; the IL-8 level in serum from the inhabitant of polluted area （ （0.31 ±0.17） μg/L） was higher than that from the control area （ （0.09 ±0.03） μg/L） （P 〈0.05） ;the TNF level in serum from the inhabitant of polluted area （ （ 0.46 ± 0.34 ） μg/L） was higher than that from the control area （ （0.16 ± 0.08 ） μg/L） （ P 〈 0.05 ） ; the IFN-γ level in serum from the inhabitant of polluted area （（ 18.65 ± 1.83） ng/L） was lower than that from the control area （（20.37 ± 0.86） μg/L） （P 〈 0.05 ）. Conclusion There were impacts on human＇s immune system exposed to PM10.