摘要
To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinom(aP<0.05). The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.
To explore the role of Human papillomavirus （HPV） in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma（P〈0.05 ）. The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein
基金
Conducting item from HeilongJiang Land-reclamating General(HNKXIVID-009)
关键词
乳癌
治疗方法
乳突淋瘤
临床分析
Mammarycarcinoma
Human papillomavirus （HPV）
Inducible nitric oxide synthase
P53 protein
Human telomerase reverse transciptase
