PRL-3磷酸酶分子生物学特性及其与大肠癌转移

Molecular biological character of PRL-3 and its relationship with colorectal cancer metastasis

PRL磷酸酶家族含有PRL-1、PRL-2和PRL-3三种分子，每种分子在不同肿瘤谱中都表现为高表达。新近研究发现，与相应正常组织和原发灶相比，PRL-3在大肠癌转移灶中表达水平和表达率明显增高，其表达水平升高与大肠癌的肝转移潜能有一定的相关性。体外大鼠实验PRL-3能显著增强转染细胞的转移、侵袭和血管生成能力。但是PRL-3通过何种机制以及与何种蛋白相互作用促进大肠癌的转移还有待进一步探讨。对PRL-3的深入研究有望使其成为大肠癌转移诊断和治疗的特异靶点。

The phosphatase of regenerating liver （PRL） families of phosphatases, consisting of PRL- 1, PRL-2, and PRL-3, are individually overexpressed in a variety of cancer cell lines and tissues when compared with their normal counterparts. Several recent studies have shown that PRL-3 is expressed at a higher level and at a greater frequency in colorectal cancer with liver metastases compared with primary colorectal tumors and normal colon tissue. Expression of PRL can enhance metastatic and invasive properties of cells and initiate tumor angiogenesis in experimental mice. However, the exact mechanism and interacting proteins of the PRL remain unclear. With further study, PRL-3 may server as an attractive target for therapeutic intervention and marker for colon cancer metastasis.