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Ixabepilone(Ixempra) 被引量:8

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作者 孙蕊 胡春
机构地区 沈阳药科大学
出处 《中国药物化学杂志》 CAS CSCD 2008年第3期240-240,共1页 Chinese Journal of Medicinal Chemistry
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参考文献5

  • 1U S FDA, FDA approves ixabepilone for injection(lxempra) for two indications [ EB/OL ]. [ 2007 - 08 - 18 ], http:// www, fda. gov/cder/Offices/OODP/whatsnew/ixabepilone. htm.
  • 2LI W S, THORNTON J E, GUO Z R, et al. A process for the preparation of epothilone analogs and intermediates: WO, 2002/060904 [ P]. 2002 - 08 - 08.
  • 3KIM S H, BORZILLERI R M. A process for the preparation of rlng-opened epothilone intermediates which are useful for the preparation of epothilone analogs: WO, 1999/27890 [ P]. 1999 - 06 - 10.
  • 4BORZILLERI R M, ZHENG X, SCHMIDT R J, et al. A novel application of a Pd(0)-catalyzed nucleophilic substitution reaction to the regioand stereoselective synthesis of lactam analogues of the epothilone natural products[J] .J Am Chem Soc, 2000, 122 (37) :8890- 8897.
  • 5阎家麒.天然产物埃坡西龙B内酰胺衍生物的合成方法:CN,1554659[P].2004-12-15.

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同被引文献129

  • 1刘贤贤.抗癌新药埃博霉素[J].桂林师范高等专科学校学报,2006,20(4):170-174. 被引量:1
  • 2罗立新,陆一鸣,潘力.NTG诱变选育埃博霉素高产菌株的研究[J].现代食品科技,2007,23(3):1-3. 被引量:5
  • 3阎家麒.天然产物埃坡西龙B内酰胺衍生物的合成方法:CN,1554659[P].2004-12-15.
  • 4Hofle G H, Bedorf H, Steinmetz H, et al. Epothilone A and B-Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution [J]. AngewChem Int Ed Engl, 1996,35:1567.
  • 5Girth K, Bedorf N, HOfle G, etal. Epothilone A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria) Production, Physico-chemical and Biological Properities[J]. J Antibiol, 1996,49: 560.
  • 6Hofle G, Glaser N, Leibold T, etal. Semisynthesis and deg radation of the tubulin inhibitors epothilone and tubulysin [J]. Pure Appl Chem, 2003,75.. 167.
  • 7Su DS, Ballog A, Meng D. Total synthesis of epothilone B: An extension of the Suzuki coupling method and insights into structure-activity relationships of the Epothilones[J]. Angezv Chem Int Ed, 1997,36:757.
  • 8Meng D, Kamenecka T, Danishefsky S, et al. Second generation epothilones: discovery of fludelone and its extraordinary antitumor properties[J]. Ange'w Chem Int Ed , 1996,35: 2801.
  • 9Schinzer D, Limberg A, Bauer A, et al. Total Synthesis of (-)-Epothilone A[J]. Angevo Chem Int Ed , 1997,:36: 523.
  • 10Nicolaou KC, He Y, Vourloumis D, et al. The olefin Metathesis Approach to Epothilone A and Its Analogues[J]. JAm Chem Soc, 1997,119:7960.

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