难治性咽喉炎与胃食管反流病的相互关系

The interrelationship between refractory laryngopharyngitis and gastroesophageal reflux disease

目的:探讨难治性咽喉炎与胃食管反流病(gastroesophageal reflux disease,GERD)的相互关系。方法:450例具有反酸、呃逆症状的难治性咽喉炎门诊患者给予胃镜、喉镜检查。结果:450例患者中有胃黏膜点状出血斑、黏膜糜烂295例(65%)、胆质反流46例(10%)、杓状关节、梨状窝组织有充血水肿、点出血灶421例(93%)。结论:难治性咽喉炎与胃食管反流关系密切,经抑制胃酸、质子泵抑制剂、阿莫西林治疗后反酸、呃逆、咽喉异物感、咳嗽、咽喉烧灼性疼痛症状得到缓解或改善。

Objective ：To investigate the interrelationship between refractory pharyngolaryngitis and gastroesophageal reflux disease. Methods：The examination of gastroscope and laryngoscope was utilized in 450 patients with refractory pharyngolaryngitis who had symptoms of sour regurgitation and singultus in out-patient department. Results：295 （65%） patients were found mucosal bleeding point and mucosal erosion in stomach ;46 （10%） patients were found bile regurgitation;421 （93%） were found hyperemia and oedema and bleeding point in sinus piriformis and arytenoid cartilages.Conclusion：The interrelationship between refractory pharyngolaryngitis and gastroesophageal reflux disease is considerablely close.The symptoms of sour regurgitus, singultation, pharyngeal paraesthesia, begma and cauterization ache would be relief or amelioration after management of amoxicillin, proton pump inhibitor and inhibitor of gastric acid.