阿奇霉素与左氧氟沙星序贯治疗社区获得性肺炎70例分析

Comparison the curative effect between Azithromycin and Levofloxacin

目的比较阿奇霉素与左氧氟沙星序贯治疗社区获得性肺炎的临床疗效。方法回顾性分析我院2006年1月至2007年1月阿奇霉素与左氧氟沙星序贯治疗社区获得性肺炎患者的临床疗效。结果共纳入患者79例,阿奇霉素组40例,左氧氟沙星组39例,两组在临床症状体征(咳嗽、咳痰、发热、胸痛、肺部啰音)以及X线胸片、痰细菌培养、血清支原体抗体检测等方面没有显著性差异。两组临床疗效比较,阿奇霉素组总有效率为70.0%,出现不良反应2例,表现为轻度恶心,上腹部不适;左氧氟沙星组总有效率为84.6%,出现不良反应3例,其中恶心等胃肠道反应1例,皮疹2例;两组临床疗效有显著性差异。结论左氧氟沙星是经验性治疗社区获得性肺炎的有效、安全的抗生素,但是,应当注意氟喹诺酮有引起伪膜性肠炎的可能。

Objective Compare the curative effect between Azithromycin and Levofloxacin, Methods Retrospective analysis the sequential therapy effect of community acquired pneumonia between Azithromycin and Levofloxacin, Results We chose 79 patients to study, 40 cases used Azithromycin, and 39 cases used Levofloxacin, both groups didnt have significant difference in clinical manifestation（ cough, expectoration, fever, chest pain, et al）, X -ray of chest, bacterial culture, and detection mycoplasma antibody, The total effective rate of Azithromycin group was 70%, 2 cases had adverse reaction （ nausea, epigastric discomfort）, The total effective rate of Levofloxacin was 84.6%, 3 cases had adverse reaction （ nausea and exanthema）, There were significant difference between the two groups, Conclusion Levofloxacin is effective and safe antibiotics of experiential therapy community acquired pneumonia, but it may cause pseudomembranous enterocolitis.