低T_3综合征早产儿治疗的临床观察

Clinical observation of the treatment in premature infants with low T_3 syndrome

目的探讨低T3综合征早产儿早期治疗的临床意义。方法将78例28～32周低T3综合征早产儿随机分为两组,治疗组给予甲状腺素替代治疗,观察两组临床情况、甲状腺素水平、神经系统发育情况的变化,应用t检验和χ2检验进行比较。结果两组T3和FT3水平均随原发病的好转及年龄的增长逐渐恢复,生后4周时两组间有显著性差异(P<0.05),生后6周时两组间无显著性差异(P>0.05)。对两组患儿的体重恢复时间、黄疸持续时间、住院天数、静脉营养时间进行比较,两组间有显著性差异(P<0.05);而校正胎龄40周时的NABA评分及1岁时的CDCC测试无显著性差异(P>0.05)。结论对低T3综合征早产儿进行早期干预治疗可以改善临床情况,促进早期恢复。

Objective To investigate the clinical significance of early treatment in premature infants with low T3 syndrome. Methods A total of 78 premature infants with low T3 syndrome were randomly divided into two groups. The reatment group were given thyroxine replacement therapy. Clinical conditions,thyroxine levels,nervous system development were observed in two groups and compared with t-test, χ^2 test. Results Serum T3 and FT3 level were gradually resumed with the improvement of the primary disease and age growth. There were significant difference at 4 weeks（P〈0.05） after birth and no significant difference at 6 weeks （P〉0.05） in two groups. Compared weight recovery time, the duration of jaundice, length of hospitalization, intravenous nutrition time in two groups, there were no significant difference（P〉0.05）. Conclusion The early treatment to the premature infants with low T3 syndrome can improvement clinical conditions and promote the early rehabilitation.