摘要
目的:观测糖尿病大鼠视觉诱发电位(VEP)的改变以及神经生长因子(NGF)和氨基胍(AG)对其的影响。方法:用链脲佐菌素(STZ)制作糖尿病大鼠动物模型,分为正常对照组(CON组)、糖尿病对照组(DM组)、糖尿病NGF治疗组(D+N组)、糖尿病AG治疗组(D+A组)。分别于病程3、6、9、12个月进行各组大鼠的VEP测定。结果:与CON组相比,其他各组大鼠在各实验时点的VEP潜伏期延长、波幅下降(P<0.01);6个月及9个月时,D+N组及D+A组的潜伏期均较DM组缩短,且差异显著(P<0.05).而波幅仅见6个月时部分回升;12个月时,除D+A组波幅较DM组略有回升外,其余改变与9个月时类似。结论:NGF和AG能够改善DM导致的大鼠VEP潜伏期延长及波幅下降。
Objective:To observe the changes of visual evoked potential (VEP) in diabetic rats and the influence of nerve growth factor (NGF) and aminoguanidine (AG) on VEP. Methods: Diabetes was induced in adult male Wistar rats with streptozotocin (STZ). Rats were divided into normal control group (CON),diabetes model group (DM), NGF-treated group (D+N) and AG-treated group(D+ A). VEP was measured during the 3rd month, 6^th month, 9^th month,and 12^th month. Results: Compared with the CON group,all rest groups had longer latencies and lower amplitudes (P〈0. 01). During the 6^th and 9^th months, the latencies in group D+N and group D+A were significantly decreased (P〈0.05) compared with DM group, and the amplitude was partially recoved during the 6^th month. The changes during the 12^th month were similar to those of the 9^th month, except that the amplitude in D+A group was slightly higher than that in the DM group. Conclusion: NGF and AG can improve DM-induced elongation of VEP latency and decrease of VEP amplitude.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2008年第6期655-658,共4页
Academic Journal of Second Military Medical University
关键词
糖尿病
视觉诱发电位
神经生长因子
氨基胍
diabetes mellitus
visual evoked potential
nerve growth factor
aminoguanidine