冠状动脉介入治疗对冠心病血浆超敏C反应蛋白和单核细胞趋化因子-1水平的影响被引量：6

Changes of plasma high-sensitive C-reactive protein and monocyte chemotactic factor-1 following percutaneous coronary interventional procedures in patients with coronary artery disease

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摘要目的通过测定冠心病病人行冠状动脉介入治疗前后血浆超敏C反应蛋白(hs-CRP)及单核细胞趋化因子-1(MCP-1)水平的改变,探讨冠状动脉介入治疗对冠心病病人炎症指标及术后再狭窄的影响。方法连续入选经冠状动脉介入治疗单支病变的冠心病病人80例,40例经冠状动脉造影证实冠状动脉正常的人作为对照组。分别采用免疫浊度法和酶联免疫吸附法检测入选病人冠状动脉介入治疗前后hs-CRP和MCP-1水平。结果(1)冠状动脉介入组病人术后血浆hs-CRP为(2.37±0.56)μg/L,显著高于术前的(1.59±0.41)μg/L(P<0.01),而对照组冠状动脉造影术后hs-CRP为(1.18±0.37)μg/L与术前的(1.13±0.32)μg/L相比差异无统计学意义(P>0.05)。(2)冠状动脉介入组病人术后血浆MCP-1为(26.04±5.43)pg/L,显著高于术前的(18.07±4.30)pg/L(P<0.01),而对照组冠脉造影术后MCP-1为(9.80±2.64)pg/L,与术前的(9.63±2.52)pg/L相比差异无统计学意义(P>0.05)。结论冠脉介入治疗促进冠心病病人血浆hs-CRP及MCP-1水平的升高,是否为冠脉介入治疗术后支架内再狭窄的重要机制之一尚待进一步考证。 Objective To investigate the changes of high-sensitive C-reactive protein （hs-CRP） and monocyte chemotactic factor-1 （MCP-1） following percutaneous coronary interventional procedures （PCI） in patients with coronary artery disease （CAD）, and evaluate the impact of PCI on the inflammatory indices and postoperative vascular restenosis. Methods This study involved 80 patients undergoing PCI procedures for CAD compromising a single coronary artery. Forty healthy individuals with normal findings by coronary angiography were selected as the control group. Before and after PCI or coronary angiography, plasma hs-CRP and MCP-1 were measured in all the subjects by immunonephelometry and enzyme-linked immunosorbant assay （ELISA）, respectively. Results In the CAD patients, the plasma hs-CRP level was significantly elevated after PCI as compared with the preoperative level （2.37±0.56μg/L vs 1.59±0.41 μg/L, P〈0.01）, whereas in the control group, the hs-CRP level underwent no significant changes after coronary angiography （1.18±0.37 μg/L vs the preoperative level of 1.13±0.32μg/L, P〉0.05）. PCI procedures also resulted in significant elevation of plasma MCP-1 level in the CAD patients （26.04±5.43 pg/L vs the preoperative level of 18.07±4.30 pg/L, P〈0.01）, but in the control group, MCP-1 showed no significant variation after coronary angiography （9.80 ±2.64 pg/L vs the preoperative level of 9.63 ±2.52 pg/L, P〉0.05）. Conclusion Plasma hs-CRP and MCP-I are elevated in CAD patients following PCI procedures, but their roles in the vascular restenosis following the procedures need further investigation.

作者王守力韩雅玲刘丽军阎承惠康健

机构地区第四军医大学西京医院心内科沈阳军区总医院全军心血管病研究所心内科邯郸市第一医院心内科

出处《南方医科大学学报》 CAS CSCD 北大核心 2008年第6期1073-1075,共3页 Journal of Southern Medical University

关键词冠心病超敏C反应蛋白单核细胞趋化因子-1 coronary artery disease high sensitive C reactive protein monocyte chemotactic factor- 1

分类号 R541.4 [医药卫生—心血管疾病]

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