病毒性心肌炎患儿心肌肌钙蛋白T和高敏C-反应蛋白及其检测的意义

Detection of cardiac troponin and high-sensitivity C reactive protein in children with viral myocarditis

目的探讨儿童病毒性心肌炎(VMC)血清心肌肌钙蛋白T(cTnT)和高敏C反应蛋白(hs-CRP)的变化及临床意义。方法测定40例VMC患者cTnT、hs-CRP和肌酸激酶同功酶(CK-BM)水平。结果VMC组入院时血清cTnT、hr-CRP和CK-MB水平明显高于对照组(P<0.01),治疗2周后cTnT、hr-CRP和CK-MB明显降低(P<0.01);入院时cTnT和hs-CRP阳性检出率明显增高,治疗2周后阳性检出率明显降低,cTnT和hs-CRP阳性检出率明显高于CK-MB(P<0.05)。结论检测血清cTnT和hs-CRP是诊断VMC的敏感指标,cTnT和hs-CRP对VMC病情预测亦具重要作用。

Objective To investigate the changes of cardiac T troponin （cTnT） and high-sensitivity C reactive protein （hs-CRP） in children with viral myocarditis （VMC）. Methods Forty children with VMC were examined for cTnT, hs-CRP, and creatine kinase MB （CK-MB） levels. Results Children with VMC had significantly higher cTnT, hs-CRP and CK-MB levels than the control group on admission （P〈0.01）, but obviously decreased after two weeks of treatment. The positivity rate of cTnT and hs-CRP were significantly higher in children with VMC than the control group on admission, and decreased significantly after treatment （P〈0.01）. The positivity rate ofcTnT and hs-CRP were significantly higher than that of CK-MB （P〈0.05）. Conclusion Serum cTnT and hs-CRP are sensitive indices for diagnosis of VMC, and their detection have important value in estimation of the patients＇ condition.