糖耐量异常患者血清铁蛋白水平的变化和意义

Clinical implications of serum ferritin concentration in patients with impaired glucose tolerance

目的:探讨血清铁蛋白与糖耐量异常(IGT)和胰岛素抵抗的关系。方法:采集测定40例患者(IGT组)(体型正常和肥胖各20例)及40名健康人(对照组)的铁蛋白和胰岛素水平,并同时检测糖化血红蛋白、空腹血糖、餐后血糖、空腹C肽、HOMA指数、李光伟指数。结果:①IGT患者血清铁蛋白浓度与糖化血红蛋白水平相关,与其他指标值不相关。②健康人组血清铁蛋白浓度与各项指标均不相关。③IGT患者血清铁蛋白浓度明显高于健康人组,空腹血胰岛素均值在IGT患者和健康人两组间无差异,而稳态模式评估法(HOMA)指数、李光伟指数在两组间均有差异。结论:IGT患者血清铁蛋白明显升高,铁蛋白与糖代谢有关,铁蛋白可能是胰岛素抵抗的预测指标。

Objective： To investigate the relationship between the serum ferritin concentration and insulin resistance in patients with impaired glucose tolerance （IGT）. Methods： The serum ferritin concentration and insulin levels were measured in 40 IGT patients （20 with normal body weight and 20 with obesity）, and 40 healthy controls. Blood glucose levels, HbA1C, blood adipose and urine protein concentration were obtained simultaneously. Results： In the IGT patients, the serum ferritin concentration was correlated with Hbal c but not with any other indexes, and it was significantly higher than in the normal controls. Significant differences were observed between the two groups in all the indexes but the fasting insulin level. Conclusion： The serum ferritin concentration increases in IGT patients, which implicates some association of ferritin with glucose metabolism and insulin resistance.