餐后高血糖与心血管疾病关系探讨

Correlation between postprandial hyperglycemia and cardiovascular disease

目的:探讨餐后高血糖与心血管疾病的相关性。方法:观察空腹血糖受损(IFG)、糖耐量异常(IGT)及糖尿病(DM,以餐后血糖升高为主)3组患者心血管疾病患病率,以及3组患者心血管疾病危险性指标:颈动脉内膜中层厚度(CIMT)、血脂(TC、TG、HDL-C、LDL-C)、体质指数(BMI)、血压(SBP、DBP)、C反应蛋白(CRP)等值的变化,并分析餐后高血糖与这些心血管疾病危险因素的关系。结果:IGT、DM组心血管危险性指标明显高于IFG组(P<0.01),DM组心血管危险性指标较IGT组升高(P<0.05);IGT、DM组心血管疾病的患病率明显高于IFG组(P<0.01),DM组心血管疾病的患病率明显高于IGT组,但差异无统计学意义。相关性分析表明:餐后高血糖与心血管危险性指标呈正相关,而与HDL-C呈负相关。结论:餐后高血糖增加心血管疾病患病率,应重视餐后高血糖,降低心血管疾病患病率。

Objective： To investigate the relationship between postprandial glucose and cardiovascular disease. Methods： Ninety-four patients were divided into an IFG, an IGT and a DM group, and observed for the incidence of cardiovascular disease and the risk indexes of cardiovascular disease, such as CIMT, TC, TG, HDL-C, LDL-C, BMI, SBP, DBP and CRP. The correlation between postprandial glucose and the risk indexes were analyzed. Results： The risk indexes were obviously higher in the IGT and DM groups than in the IFG group （P 〈 0.01 ）, and so were they in the DM than in the IGT group （P 〉0.01 ）. Postprandial glucose was correlated positively with the risk indexes, but negatively with HDL-C. Conclusion： Postprandial hyperglycemia increases the incidence of cardiovascular disease.