蛋白质组学技术及其在肺癌诊断研究中的应用进展

Proteomic technology and its application in the early diagnosis of lung cancer

肺癌是目前最常见的恶性肿瘤,由于缺乏有效的早期诊断手段,死亡率高,预后差。恶性肿瘤与正常组织或血清蛋白质组学的研究,可直接比较两者之间蛋白质组学的表达差异,为我们发现新的肿瘤标记物提供了可能,从而为肺癌的早期诊断提供一条新的途径。现简要介绍目前常用的诊断蛋白质组学研究方法及其各种方法在肺癌蛋白质组学研究中的最新进展。

Lung cancer is the most frequently seen malignancy in the world in terms of incidence. For lack of effective diagnostic method in the early stage, it is notorious for poor prognosis and high mortality. Direct measurement of abnormally expressed or modified proteins in the tumor tissue and/or the patient＇ s blood may be an effective approach to the discovery of new biomarkers, as well as a new way for the early diagnosis of lung cancer. This article reviews some clinical proteomic technologies and their successful applications to lung cancer proteomics.