期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞周期依赖性蛋白激酶(CDK)抑制剂Xylocydine合成研究进展 被引量：1

Research Progress on Synthesis of Xylocydine--a Novel Inhibitor of Cyclin-Dependent Kinases
下载PDF
导出
摘要 介绍了细胞周期依赖性蛋白激酶(CDK)抑制剂Xylocydine的发现及其生物活性,并综述了Xylocydine合成路线的研究进展。 Xylocydine is a novel inhibitor of cyclin-dependent kinases, it＇s discovery and bioactivity are introduced and the recent progress on the synthesis of Xylocydine is reviewed.
作者 张慧敏 尹静梅 高大彬 陈惠麟 周广运 贾颖萍
机构地区 大连大学 生物有机化学辽宁省重点实验室 中国科学院 大连化学物理研究所
出处 《大连大学学报》 2008年第3期23-26,共4页 Journal of Dalian University
基金 辽宁省教育厅高等学校科学技术研究项目(20040046)
关键词 Xylocydine CDK抑制剂 生物活性 合成 核苷 Xylocydine CDK inhibitor biological activity synthesis nucleoside
分类号 O629.8 [理学—有机化学]
  • 相关文献

参考文献22

  • 1[1]Attisano L,Wrana J L.Signal transduction by members of the transforming growth factor-beta superfamily[J].Cytokine Growth Factor Rev,1996,7(4):327-339.
  • 2[2]Buchkovich K,Duffy L A,Harlow E.The retinoblastoma protein is phosphorylated during specific phases of the cellcycle[J].Cell,1989,58(6):1097-1105.
  • 3[3]Meijer L,Leclerc S,Leost M.Properties and potential applications of chemical inhibitors of cyclin-dependent kinases[J].Pharmacol Ther,1999,82:279-284.
  • 4[4]Senderowicz A M,Sausvile E A.Preclinical and clinical development of cyclin-dependent kinase modulators[J].J.Natl.Cancer.Inst,2000,92:376-387.
  • 5[5]Park S G,Cheon J Y,Lee Y H,et al.Isolation of hrp2(+) gene,a new member of SNF2/SWI2 family from fission yeast Schizosaccharomyces pombe[J].Mol.Cells,1996,6:679-683.
  • 6[6]Chun M W,Shin D H,Song S Y,et al.Synthesis of L-sangivamycin and toyocamycin analogues and their inhibitory activities of Ser Thr protein kinases[J].Nucleosides Nucleotides,1999,18:617-618.
  • 7[7]Ham Y M,Choi K J,Song S Y,et al.Xylocydine,a Novel Inhibitor of Cyclin-Dependent Kinases,Prevents the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptotic Cell Death of SK-HEP-1 Cells[J].JPET,2004,308(3):814-819.
  • 8[8]Chun M W,Lee S K.Novel Inhibitors of Cell Cycle-RelatedKinases[P].Korean Patent,10-0385281-0000,2001-12-28.
  • 9[9]Middleton W J,Engelhart V A,Fisher B S.Cyanocarbon Chemistry.Ⅷ.1 Heterocyclic Compounds from Tetracyanoethylene[J].J.Chem.Soc.,1958,80(11):2822-2829.
  • 10[10]Middleton W J,Heckert R E,Little E L,et al.Cyanocarbon Chemistry.Ⅲ.1 Addition Reactions of Tetracyanoethylene[J].J.Am.Chem.Soc.,1958,80(11):2783-2788.

二级参考文献5

  • 1Balagopala MI, Ollapally AP, Lee HJ.An improved synthesis of azidothymidine [J].Nucleosides Nucleotides, 1996, 15 (4):899-906.
  • 2Niedballa U, Vorbruggen H.A general synthesis of Nglycosides.I.Synthesis of pyrimidine nucleosides [J].J Org Chem, 1974, 39 (25): 3654-3660.
  • 3Holy A.Preparation of acyl derivatives of pyrimidin-2-one nuclesides by the silyl variant of the Hilbert-Johnson reaction[J].Collect Czecho Chem Commun, 1974, 42 (3): 902-908.
  • 4Fox JJ, Yung N, Davoll J, et al.Pyrimedine nucleosides.Ⅰ .A new route for the synthesis of thymine nucleosides [J].J Am Chem Soc, 1956, 78 (5): 2117-2122.
  • 5Nakayama C, Saneyoshi M.Synthetic nucleosides and nucleotides.X X.Synthesis of various 1-β-D-xylofuranosyl-5-alkyluracils and related nucleosides [J].Nucleosides Nucleotides, 1982, 1 (2): 139-146.

共引文献2

同被引文献20

  • 1康振生 李振岐.洛夫林10常温致病新菌系的发现[J].西北农学院学报,1984,12(4):18-28.
  • 2Hartwell LH, Culotti J, Reid B. Genetic control of the cell-division cycle in Yeast. I. Detection of mutants. Proceedings of the National Academy of Sciences, 1970, 66(2) : 352-359.
  • 3Bordon-Pallier F, Jullian N, Haesslein JL. The cell cycle of pathogenic fungi: target for drugs. Progress in Cell Cycle Research, 2003, 5: 81-90.
  • 4Thomas CF, Jr. Anders RA, Gustafson MP, et al. Pneumocystis carinii contains a functional cell-division- cycle Cdc2 homologue. American Journal of Respiratory Cell and Molecular Biology, 1998, 18 : 297-306.
  • 5Chen JY, Zhou S,Wang Q, et al. Crkl, a novel Cdc2- related protein kinase, is required for hyphal development and virulence in Candida albicans. Molecular and Cellular Biology, 2000, 23 ( 20 ) : 8696 -8708.
  • 6Garcia-Muse T, Steinberg G, Perez-Martin J. Characterization of B-type cyclins in the smut fungus Ustilago maydis : roles in morphogenesis and pathogenicity. Journal of Cell Science, 2003, 117 (3) : 487 -506.
  • 7Castillo-Lluva S, Alvarez-Tabares I, Weber Isabella, et al. Sustained cell polarity and virulence in the phytopathogenic fungus Ustilago maydis depends on an essential cyclin-dependent kinase from the CdkS/Pho85 family. Journal of Cell Science,2007, 120 : 1584-1595.
  • 8Chen XM, Line RF, Leung H. Relationship between virulence variation and DNA polymorphism in Puccinia striiformis. Phytopathology, 1993, 83: 1489-1497.
  • 9Ling P, Wang MN, Chen XM, et al. Construction and characterization of a full-length cDNA library for the wheat stripe rust pathogen (Puccinia striiformis f. sp. tritici). BMC Genomics, 2007, 8: 145.
  • 10Kenneth JL, Thomas DS. Analysis of relative gene expression data using real-time quantitative PCR and the 2T^-△△c method. Methods, 2001, 25(4) : 402-408.

引证文献1

二级引证文献4

大连大学学报
2008年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部