胆固醇氧化衍生物在动脉粥样硬化中的研究进展

Research on cholesterol oxidation derivative in Atherosclerosis

胆固醇氧化衍生物多达上百种。具有代表性质的胆固醇氧化衍生物主要有7-酮基胆固醇、7-酮基胆甾醇-9-羧基壬酸酯、25-羟基胆固醇、7β-羟基胆固醇、3β,5α,6β-三羟基胆固烷等化合物,这些衍生物广泛存在于胆固醇膳食、高胆固醇血症的血浆、动脉组织、人动脉粥样硬化斑块、斑块内的泡沫细胞、以及氧化型低密度脂蛋白中。大量实验表明胆固醇氧化衍生物对动脉粥样硬化形成有关因素(炎症、氧化应激、凋亡)具有促进作用。提示,胆固醇氧化衍生物在动脉粥样硬化的发生和发展中具有重要的作用。

Cholesterol oxidation derivatives are as many as one hundred kinds. The 7-ketocholesterol, 7-ketocholesteryl- 9-carboxynonanoate, 25-hydroxycholesterol, 7β-hydroxycholesterol and cholest-3β,5α,6β-triol are representatives of cholesterol oxidation derivatives. They are found in the foodstuffs, the blood and arterial tissues of animals with hypercholesterolemia, the human atheroma, the foam cell from atherosclerotic tissues as well as in the oxidized low density lipoprotein. The results of experiments have demonstrated that cholesterol oxidation derivatives are cytotoxic and correlate to a variety of factors of atherosclerosis including inflammation, oxidative stress, apoptosis suggesting that cholesterol oxidation derivative could play a key role in the initiation and pathogenesis of atherosclerosis.